Mature B-cell leukemias with more than 55% prolymphocytes: Report of 2 cases with Burkitt lymphoma-type chromosomal translocations involving c-myc

Shakil Merchant, Ellen Schlette, Warren Sanger, Raymond Lai, L. Jeffrey Medeiros

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Context. - The molecular genetic events involved in the pathogenesis of mature B-cell leukemias with more than 55% prolymphocytes are not well characterized. We have encountered 2 such cases in which conventional cytogenetic analysis identified Burkitt lymphoma-type chromosomal translocations involving 8q24. Objective. - To assess these 2 cases for involvement of the c-myc gene using fluorescence in situ hybridization analysis with probes specific for the c-myc and immunoglobulin heavy-chain (IgH) genes. Results. - In both cases, conventional cytogenetic analysis demonstrated complex karyotypes, including chromosomal translocations involving 8q24. In case 1, a case of de novo prolymphocytic leukemia, the t(8;14)(q24;q32) was detected. In case 2, a case of chronic lymphocytic leukemia in prolymphocytoid transformation, the t(8; 22)(q24;q11) was identified. Fluorescence in situ hybridization studies showed c-myc/IgH fusion signals in case 1, proving the presence of the t(8;14). Split c-myc signals without fusion to IgH were observed in case 2, proving cmyc gene rearrangement and consistent with the t(8;22). Conclusion. - These results suggest that c-myc gene alterations may be involved in the pathogenesis of a subset of mature B-cell leukemias with more than 55% prolymphocytes.

Original languageEnglish (US)
Pages (from-to)305-309
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Volume127
Issue number3
StatePublished - Mar 1 2003

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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