Measurement of circular intensity differential scattering (CIDS) from single airborne aerosol particles for bioaerosol detection and identification

Yong Le Pan; Aimable Kalume; Jessica Arnold; Leonid Beresnev; Chuji Wang; Danielle N. Rivera; kevin K. Crown; Joshua Santarpia

doi:10.1364/OE.448288

Measurement of circular intensity differential scattering (CIDS) from single airborne aerosol particles for bioaerosol detection and identification

Yong Le Pan, Aimable Kalume, Jessica Arnold, Leonid Beresnev, Chuji Wang, Danielle N. Rivera, kevin K. Crown, Joshua Santarpia

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The circular intensity differential scattering (CIDS), i.e. the normalized Mueller matrix element -S14/S11, can be used to detect the helical structures of DNA molecules in biological systems, however, no CIDS measurement from single particles has been reported to date. We report an innovative method for measuring CIDS phase functions from single particles individually flowing through a scattering laser beam. CIDS signals were obtained from polystyrene latex (PSL) microspheres with or without coating of DNA molecules, tryptophan particles, and aggregates of B. subtilis spores, at the size of 3 μm in diameter. Preliminary results show that this method is able to measure CIDS phase function in tens of microseconds from single particles, and has the ability to identify particles containing biological molecules.

Original language	English (US)
Pages (from-to)	1442-1451
Number of pages	10
Journal	Optics Express
Volume	30
Issue number	2
DOIs	https://doi.org/10.1364/OE.448288
State	Published - Jan 17 2022

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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10.1364/OE.448288

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abstract = "The circular intensity differential scattering (CIDS), i.e. the normalized Mueller matrix element -S14/S11, can be used to detect the helical structures of DNA molecules in biological systems, however, no CIDS measurement from single particles has been reported to date. We report an innovative method for measuring CIDS phase functions from single particles individually flowing through a scattering laser beam. CIDS signals were obtained from polystyrene latex (PSL) microspheres with or without coating of DNA molecules, tryptophan particles, and aggregates of B. subtilis spores, at the size of 3 μm in diameter. Preliminary results show that this method is able to measure CIDS phase function in tens of microseconds from single particles, and has the ability to identify particles containing biological molecules.",

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T1 - Measurement of circular intensity differential scattering (CIDS) from single airborne aerosol particles for bioaerosol detection and identification

AU - Pan, Yong Le

AU - Kalume, Aimable

AU - Arnold, Jessica

AU - Beresnev, Leonid

AU - Wang, Chuji

AU - Rivera, Danielle N.

AU - Crown, kevin K.

AU - Santarpia, Joshua

PY - 2022/1/17

Y1 - 2022/1/17

N2 - The circular intensity differential scattering (CIDS), i.e. the normalized Mueller matrix element -S14/S11, can be used to detect the helical structures of DNA molecules in biological systems, however, no CIDS measurement from single particles has been reported to date. We report an innovative method for measuring CIDS phase functions from single particles individually flowing through a scattering laser beam. CIDS signals were obtained from polystyrene latex (PSL) microspheres with or without coating of DNA molecules, tryptophan particles, and aggregates of B. subtilis spores, at the size of 3 μm in diameter. Preliminary results show that this method is able to measure CIDS phase function in tens of microseconds from single particles, and has the ability to identify particles containing biological molecules.

AB - The circular intensity differential scattering (CIDS), i.e. the normalized Mueller matrix element -S14/S11, can be used to detect the helical structures of DNA molecules in biological systems, however, no CIDS measurement from single particles has been reported to date. We report an innovative method for measuring CIDS phase functions from single particles individually flowing through a scattering laser beam. CIDS signals were obtained from polystyrene latex (PSL) microspheres with or without coating of DNA molecules, tryptophan particles, and aggregates of B. subtilis spores, at the size of 3 μm in diameter. Preliminary results show that this method is able to measure CIDS phase function in tens of microseconds from single particles, and has the ability to identify particles containing biological molecules.

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Measurement of circular intensity differential scattering (CIDS) from single airborne aerosol particles for bioaerosol detection and identification

Abstract

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