Measurement of circular intensity differential scattering (CIDS) from single airborne aerosol particles for bioaerosol detection and identification

Yong Le Pan, Aimable Kalume, Jessica Arnold, Leonid Beresnev, Chuji Wang, Danielle N. Rivera, kevin K. Crown, Joshua Santarpia

Research output: Contribution to journalArticlepeer-review

Abstract

The circular intensity differential scattering (CIDS), i.e. the normalized Mueller matrix element -S14/S11, can be used to detect the helical structures of DNA molecules in biological systems, however, no CIDS measurement from single particles has been reported to date. We report an innovative method for measuring CIDS phase functions from single particles individually flowing through a scattering laser beam. CIDS signals were obtained from polystyrene latex (PSL) microspheres with or without coating of DNA molecules, tryptophan particles, and aggregates of B. subtilis spores, at the size of 3 μm in diameter. Preliminary results show that this method is able to measure CIDS phase function in tens of microseconds from single particles, and has the ability to identify particles containing biological molecules.

Original languageEnglish (US)
Pages (from-to)1442-1451
Number of pages10
JournalOptics Express
Volume30
Issue number2
DOIs
StatePublished - Jan 17 2022

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Fingerprint

Dive into the research topics of 'Measurement of circular intensity differential scattering (CIDS) from single airborne aerosol particles for bioaerosol detection and identification'. Together they form a unique fingerprint.

Cite this