MECHANICAL CHARACTERIZATION OF CALCIFICAITON IN DISEASED CORONARY ARTERY WITH ATOMIC FORCE MICROSCOPE

Ana Delgado; Pengfei Dong; Mahyar Sameti; Vladislav N. Zimin; Juhwan Lee; Yazan Gharaibeh; Hiram G. Bezerra; David Wilson; Christopher Bashur; Linxia Gu

doi:10.1115/DMD2022-1055

MECHANICAL CHARACTERIZATION OF CALCIFICAITON IN DISEASED CORONARY ARTERY WITH ATOMIC FORCE MICROSCOPE

Ana Delgado, Pengfei Dong, Mahyar Sameti, Vladislav N. Zimin, Juhwan Lee, Yazan Gharaibeh, Hiram G. Bezerra, David Wilson, Christopher Bashur, Linxia Gu

Mechanical & Materials Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

In this work, the mechanical propertied of calcification in diseased coronary artery was evaluated with atomic force microscope (AFM). The heavily calcified coronary artery was harvest from a cadaver's heart. The artery slices with thickness of 10 um were prepared with cryosectioning. Staining with Alizarin Red has been performed to highlight the calcification region. Results have shown that the calcified areas have a significant larger stiffness compared with the surrounding plaque and the media layer of a healthy artery. The calcification showed a heterogeneous property with larger deviation in stiffness distribution. The staining process affected the mechanical properties. Results will enhance the mechanical property database in the literature.

Original language	English (US)
Title of host publication	Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022
Publisher	American Society of Mechanical Engineers
ISBN (Electronic)	9780791885710
DOIs	https://doi.org/10.1115/DMD2022-1055
State	Published - 2022
Event	2022 Design of Medical Devices Conference, DMD 2022 - Minneapolis, Virtual, United States Duration: Apr 11 2022 → Apr 14 2022

Publication series

Name	Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022

Conference

Conference	2022 Design of Medical Devices Conference, DMD 2022
Country/Territory	United States
City	Minneapolis, Virtual
Period	4/11/22 → 4/14/22

Keywords

AFM
atherosclerosis
calcification
coronary artery
mechanical characterization

ASJC Scopus subject areas

Biomedical Engineering
Medicine (miscellaneous)

Access to Document

10.1115/DMD2022-1055

Cite this

Delgado, A., Dong, P., Sameti, M., Zimin, V. N., Lee, J., Gharaibeh, Y., Bezerra, H. G., Wilson, D., Bashur, C., & Gu, L. (2022). MECHANICAL CHARACTERIZATION OF CALCIFICAITON IN DISEASED CORONARY ARTERY WITH ATOMIC FORCE MICROSCOPE. In Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022 Article V001T01A004 (Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022). American Society of Mechanical Engineers. https://doi.org/10.1115/DMD2022-1055

MECHANICAL CHARACTERIZATION OF CALCIFICAITON IN DISEASED CORONARY ARTERY WITH ATOMIC FORCE MICROSCOPE. / Delgado, Ana; Dong, Pengfei; Sameti, Mahyar et al.
Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022. American Society of Mechanical Engineers, 2022. V001T01A004 (Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Delgado, A, Dong, P, Sameti, M, Zimin, VN, Lee, J, Gharaibeh, Y, Bezerra, HG, Wilson, D, Bashur, C & Gu, L 2022, MECHANICAL CHARACTERIZATION OF CALCIFICAITON IN DISEASED CORONARY ARTERY WITH ATOMIC FORCE MICROSCOPE. in Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022., V001T01A004, Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022, American Society of Mechanical Engineers, 2022 Design of Medical Devices Conference, DMD 2022, Minneapolis, Virtual, United States, 4/11/22. https://doi.org/10.1115/DMD2022-1055

Delgado A, Dong P, Sameti M, Zimin VN, Lee J, Gharaibeh Y et al. MECHANICAL CHARACTERIZATION OF CALCIFICAITON IN DISEASED CORONARY ARTERY WITH ATOMIC FORCE MICROSCOPE. In Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022. American Society of Mechanical Engineers. 2022. V001T01A004. (Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022). doi: 10.1115/DMD2022-1055

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title = "MECHANICAL CHARACTERIZATION OF CALCIFICAITON IN DISEASED CORONARY ARTERY WITH ATOMIC FORCE MICROSCOPE",

abstract = "In this work, the mechanical propertied of calcification in diseased coronary artery was evaluated with atomic force microscope (AFM). The heavily calcified coronary artery was harvest from a cadaver's heart. The artery slices with thickness of 10 um were prepared with cryosectioning. Staining with Alizarin Red has been performed to highlight the calcification region. Results have shown that the calcified areas have a significant larger stiffness compared with the surrounding plaque and the media layer of a healthy artery. The calcification showed a heterogeneous property with larger deviation in stiffness distribution. The staining process affected the mechanical properties. Results will enhance the mechanical property database in the literature.",

keywords = "AFM, atherosclerosis, calcification, coronary artery, mechanical characterization",

author = "Ana Delgado and Pengfei Dong and Mahyar Sameti and Zimin, {Vladislav N.} and Juhwan Lee and Yazan Gharaibeh and Bezerra, {Hiram G.} and David Wilson and Christopher Bashur and Linxia Gu",

note = "Funding Information: This project was supported by the National Heart, Lung, and Blood Institute through grant R01 HL143484. The grant was obtained via collaboration between Case Western Reserve University, University Hospitals of Cleveland, and Florida Institute of Technology. The content of this report is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2022 by ASME; 2022 Design of Medical Devices Conference, DMD 2022 ; Conference date: 11-04-2022 Through 14-04-2022",

year = "2022",

doi = "10.1115/DMD2022-1055",

language = "English (US)",

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AU - Delgado, Ana

AU - Dong, Pengfei

AU - Sameti, Mahyar

AU - Zimin, Vladislav N.

AU - Lee, Juhwan

AU - Gharaibeh, Yazan

AU - Bezerra, Hiram G.

AU - Wilson, David

AU - Bashur, Christopher

AU - Gu, Linxia

N1 - Funding Information: This project was supported by the National Heart, Lung, and Blood Institute through grant R01 HL143484. The grant was obtained via collaboration between Case Western Reserve University, University Hospitals of Cleveland, and Florida Institute of Technology. The content of this report is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: © 2022 by ASME

PY - 2022

Y1 - 2022

N2 - In this work, the mechanical propertied of calcification in diseased coronary artery was evaluated with atomic force microscope (AFM). The heavily calcified coronary artery was harvest from a cadaver's heart. The artery slices with thickness of 10 um were prepared with cryosectioning. Staining with Alizarin Red has been performed to highlight the calcification region. Results have shown that the calcified areas have a significant larger stiffness compared with the surrounding plaque and the media layer of a healthy artery. The calcification showed a heterogeneous property with larger deviation in stiffness distribution. The staining process affected the mechanical properties. Results will enhance the mechanical property database in the literature.

AB - In this work, the mechanical propertied of calcification in diseased coronary artery was evaluated with atomic force microscope (AFM). The heavily calcified coronary artery was harvest from a cadaver's heart. The artery slices with thickness of 10 um were prepared with cryosectioning. Staining with Alizarin Red has been performed to highlight the calcification region. Results have shown that the calcified areas have a significant larger stiffness compared with the surrounding plaque and the media layer of a healthy artery. The calcification showed a heterogeneous property with larger deviation in stiffness distribution. The staining process affected the mechanical properties. Results will enhance the mechanical property database in the literature.

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KW - atherosclerosis

KW - calcification

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KW - mechanical characterization

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MECHANICAL CHARACTERIZATION OF CALCIFICAITON IN DISEASED CORONARY ARTERY WITH ATOMIC FORCE MICROSCOPE

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

Access to Document

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