TY - GEN
T1 - Mechanical characterization of the decellularized porcine small intestinal submucosa extracellular matrix
AU - Zhao, Shijia
AU - Gu, Linxia
AU - Hammel, James M.
AU - Lang, Haili
PY - 2013
Y1 - 2013
N2 - In this work, the decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM), obtained from the commercial product under the trade name of CorMatrix, were tested in uniaxial tension. Preconditioning under cyclic loading of 2 N was conducted to stabilize the mechanical response of the tissue. The influence of rehydration time on the mechanical properties of the tissue was evaluated. Results suggested that the stiffness of SIS-ECM decreased with longer rehydration time. Considering the application of CorMatrix in pericardial closure, the native pericardium samples were also tested. The comparison indicated that the native pericardium is softer than rehydrated CorMatrix. This work can facilitate the surgeons to better choose the appropriate rehydration time when conducting the extracardiac implantations, such as pericardial reconstruction, pericardial closure, etc.
AB - In this work, the decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM), obtained from the commercial product under the trade name of CorMatrix, were tested in uniaxial tension. Preconditioning under cyclic loading of 2 N was conducted to stabilize the mechanical response of the tissue. The influence of rehydration time on the mechanical properties of the tissue was evaluated. Results suggested that the stiffness of SIS-ECM decreased with longer rehydration time. Considering the application of CorMatrix in pericardial closure, the native pericardium samples were also tested. The comparison indicated that the native pericardium is softer than rehydrated CorMatrix. This work can facilitate the surgeons to better choose the appropriate rehydration time when conducting the extracardiac implantations, such as pericardial reconstruction, pericardial closure, etc.
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U2 - 10.1115/IMECE2013-65640
DO - 10.1115/IMECE2013-65640
M3 - Conference contribution
AN - SCOPUS:84903485998
SN - 9780791856215
T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
BT - Biomedical and Biotechnology Engineering
PB - American Society of Mechanical Engineers (ASME)
T2 - ASME 2013 International Mechanical Engineering Congress and Exposition, IMECE 2013
Y2 - 15 November 2013 through 21 November 2013
ER -