Mechanical contribution of vascular smooth muscle cells in the tunica media of artery

Hozhabr Mozafari, Changchun Zhou, Linxia Gu

Research output: Contribution to journalReview article

Abstract

The stiffness of arterial wall in response to cardiovascular diseases has been associated with the changes in extracellular matrix (ECM) proteins, i.e., collagen and elastin. Vascular smooth muscle cells (VSMCs) helped to regulate the ECM reorganizations and thus contributed to arterial stiffness. This article reviewed experimental and computational studies for quantifying the roles of ECM proteins and VSMCs in mechanical properties of arteries, including nanostructure and mechanical properties of VSMCs and ECMs, cell-ECM interaction, and biomimetic gels/scaffolds induced contractile properties and phenotype changing of VSMCs. This work will facilitate our understanding of how the microenvironments and mechanotransduction impact and regulate the arterial adaptation.

Original languageEnglish (US)
Pages (from-to)50-60
Number of pages11
JournalNanotechnology Reviews
Volume8
Issue number1
DOIs
StatePublished - 2019

Keywords

  • Artery
  • Collagen
  • Contraction
  • Elastin
  • Finite element method
  • Hypertension
  • Tunica media
  • Vascular smooth muscle cell

ASJC Scopus subject areas

  • Biotechnology
  • Medicine (miscellaneous)
  • Materials Science (miscellaneous)
  • Energy Engineering and Power Technology
  • Engineering (miscellaneous)
  • Process Chemistry and Technology

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