Abstract
Factors influencing the phagocytosis of mycobacteria by 33B rat Schwannoma cells and rat peritoneal macrophages were studied. Uptake of 14C-acetate-labeled Mycobacterium w by these cells was used to set up a radiometric phagocytosis assay. Incubation at 4°C and treatment with sodium azide (0.2% to 1%), cochicine (10-7 to 10-3 M), cytochalasin B (0.2 μg/ml to 25 μg/ml), and dibutyryl cyclic AMP (10-7 to 10-3 M) inhibited the phagocytosis by both cell types in a similar manner. Those experiments demonstrate similarities in the mechanism of phagocytosis of mycobacteria by Schwann cells and macrophages.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 294-299 |
| Number of pages | 6 |
| Journal | International Journal of Leprosy |
| Volume | 54 |
| Issue number | 2 |
| State | Published - 1986 |
| Externally published | Yes |
ASJC Scopus subject areas
- Dermatology