Mechanism of phagocytosis of mycobacteria by Schwann cells and their comparison with macrophages

A. H. Band, S. D. Chitamber, A. Bhattacharya, G. P. Talwar

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Factors influencing the phagocytosis of mycobacteria by 33B rat Schwannoma cells and rat peritoneal macrophages were studied. Uptake of 14C-acetate-labeled Mycobacterium w by these cells was used to set up a radiometric phagocytosis assay. Incubation at 4°C and treatment with sodium azide (0.2% to 1%), cochicine (10-7 to 10-3 M), cytochalasin B (0.2 μg/ml to 25 μg/ml), and dibutyryl cyclic AMP (10-7 to 10-3 M) inhibited the phagocytosis by both cell types in a similar manner. Those experiments demonstrate similarities in the mechanism of phagocytosis of mycobacteria by Schwann cells and macrophages.

Original languageEnglish (US)
Pages (from-to)294-299
Number of pages6
JournalInternational Journal of Leprosy
Volume54
Issue number2
StatePublished - 1986

ASJC Scopus subject areas

  • Dermatology

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