Factors influencing the phagocytosis of mycobacteria by 33B rat Schwannoma cells and rat peritoneal macrophages were studied. Uptake of 14C-acetate-labeled Mycobacterium w by these cells was used to set up a radiometric phagocytosis assay. Incubation at 4°C and treatment with sodium azide (0.2% to 1%), cochicine (10-7 to 10-3 M), cytochalasin B (0.2 μg/ml to 25 μg/ml), and dibutyryl cyclic AMP (10-7 to 10-3 M) inhibited the phagocytosis by both cell types in a similar manner. Those experiments demonstrate similarities in the mechanism of phagocytosis of mycobacteria by Schwann cells and macrophages.
|Original language||English (US)|
|Number of pages||6|
|Journal||International Journal of Leprosy|
|State||Published - 1986|
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