Mechanisms, biomarkers and targets for therapy in alcohol-associated liver injury: From Genetics to nutrition: Summary of the ISBRA 2018 symposium

Irina A. Kirpich, Dennis R. Warner, Wenke Feng, Swati Joshi-Barve, Craig J. McClain, Devanshi Seth, Wei Zhong, Zhanxiang Zhou, Natalia A. Osna, Kusum K. Kharbanda

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

The symposium “Mechanisms, Biomarkers and Targets for Therapy in Alcohol-associated Liver Injury: From Genetics to Nutrition” was held at the 19th Congress of International Society for Biomedical Research on Alcoholism on September 13th, 2018 in Kyoto, Japan. The goal of the symposium was to discuss the importance of genetics and nutrition in alcoholic liver disease (ALD) development from mechanistic and therapeutic perspectives. The following is a summary of this session addressing the gene polymorphisms in ALD, the role of zinc in gut–liver axis perturbations associated with ALD, highlighting the importance of dietary fat in ALD pathogenesis, the hepatic n6 and n3 PUFA oxylipin pattern associated with ethanol-induced liver injury, and finally deliberating on new biomarkers for alcoholic hepatitis and their implications for diagnosis and therapy. This summary of the symposium will benefit junior and senior faculty currently investigating alcohol-induced organ pathology as well as undergraduate, graduate, and post-graduate students and fellows.

Original languageEnglish (US)
Pages (from-to)105-114
Number of pages10
JournalAlcohol
Volume83
DOIs
StatePublished - Mar 2020

Keywords

  • 3-hydroxypropyl-mercapturic acid
  • Porphyromonas gingivalis
  • acrolein-adducts
  • alcoholic liver disease
  • defensin 5
  • genetic mutations
  • lipid droplets
  • oxylipins
  • perilipins
  • phosphatidylcholine
  • phosphatidylethanolamine
  • resolvins
  • zinc
  • zinc transporter

ASJC Scopus subject areas

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience

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