Abstract
Mammals cannot synthesize biotin and depend on a regular dietary supply of this water-soluble vitamin (Zempleni et al., 2009). The Adequate Intake for biotin in adults is 30 µg/d (National Research Council, 1998). The classical role of biotin in mammalian intermediary metabolism is to serve as a covalently bound coenzyme in five carboxylases (Zempleni et al., 2009). Both the cytoplasmic acetyl-CoA carboxylase 1 (ACC1) and the mitochondrial acetyl-CoA carboxylase 2 (ACC2) catalyze the binding of bicarbonate to acetyl-CoA to generate malonyl-CoA, but the two isoforms have distinct functions in intermediary metabolism (Kim et al., 1997). ACC1 produces malonyl-CoA for the synthesis of fatty acid synthesis in the cytoplasm; ACC2 is an important regulator of fatty acid oxidation in mitochondria. The malonyl-CoA produced by ACC2 inhibits mitochondrial uptake of fatty acids for Β-oxidation.
Original language | English (US) |
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Title of host publication | Vitamin-Binding Proteins |
Subtitle of host publication | Functional Consequences |
Publisher | CRC Press |
Pages | 219-228 |
Number of pages | 10 |
ISBN (Electronic) | 9781439880203 |
ISBN (Print) | 9781439880166 |
DOIs | |
State | Published - Jan 1 2013 |
ASJC Scopus subject areas
- General Medicine
- General Engineering
- General Agricultural and Biological Sciences
- General Biochemistry, Genetics and Molecular Biology