TY - JOUR
T1 - Mechanisms of hormone action
T2 - Luteinizing hormone receptors and second- messenger pathways
AU - Davis, J. S.
PY - 1994
Y1 - 1994
N2 - The binding of luteinizing hormone/chorionic gonadotropin (LH/CG) to its receptor leads to an orderly cascade of events leading to activation of cytoplasmic effector molecules. The mechanism of action of LH includes stimulation of multiple signal transduction effector systems, including adenylyl cyclase (AC) and inositol phospholipid-specific phospholipase-C (PLC). These effector systems operate by activating families of protein kinases (PKs) which regulate cell metabolism, secretion, gene induction, cellular proliferation and differentiation. The signaling pathways activated by LH interact or cross-talk with the signaling pathways activated by growth factors. The diversity of cellular signaling mechanisms elicited by LH and the potential for interactions with signals generated by growth factors may allow fine tuning of cellular responses during the process of follicular development, ovulation, and corpus luteum formation.
AB - The binding of luteinizing hormone/chorionic gonadotropin (LH/CG) to its receptor leads to an orderly cascade of events leading to activation of cytoplasmic effector molecules. The mechanism of action of LH includes stimulation of multiple signal transduction effector systems, including adenylyl cyclase (AC) and inositol phospholipid-specific phospholipase-C (PLC). These effector systems operate by activating families of protein kinases (PKs) which regulate cell metabolism, secretion, gene induction, cellular proliferation and differentiation. The signaling pathways activated by LH interact or cross-talk with the signaling pathways activated by growth factors. The diversity of cellular signaling mechanisms elicited by LH and the potential for interactions with signals generated by growth factors may allow fine tuning of cellular responses during the process of follicular development, ovulation, and corpus luteum formation.
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U2 - 10.1097/00001703-199406000-00010
DO - 10.1097/00001703-199406000-00010
M3 - Review article
C2 - 8038413
AN - SCOPUS:0028207106
VL - 6
SP - 254
EP - 261
JO - Current Opinion in Obstetrics and Gynecology
JF - Current Opinion in Obstetrics and Gynecology
SN - 1040-872X
IS - 3
ER -