Mechanisms of in situ activation of peroxidic antimalarials

Yuxiang Dong; Jonathan L. Vennerstrom

doi:10.1179/135100003225002989

Mechanisms of in situ activation of peroxidic antimalarials

Yuxiang Dong, Jonathan L. Vennerstrom

Pharmaceutical Science

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

This review describes mechanisms of action of artemisinin-related antimalarials, emphasizing the site and target of activation, pathways of generating reactive species, and possible targets of free radicals with implications for antimalarial peroxide drug design. It also presents a useful link between the mode of action of artemisinin and that of chloroquine, and highlights redox cycles involved in the interaction between the drug and vital biomolecules.

Original language	English (US)
Pages (from-to)	284-288
Number of pages	5
Journal	Redox Report
Volume	8
Issue number	5
DOIs	https://doi.org/10.1179/135100003225002989
State	Published - 2003

ASJC Scopus subject areas

Biochemistry
Physiology
Clinical Biochemistry
Cell Biology
Biochemistry, medical

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10.1179/135100003225002989

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abstract = "This review describes mechanisms of action of artemisinin-related antimalarials, emphasizing the site and target of activation, pathways of generating reactive species, and possible targets of free radicals with implications for antimalarial peroxide drug design. It also presents a useful link between the mode of action of artemisinin and that of chloroquine, and highlights redox cycles involved in the interaction between the drug and vital biomolecules.",

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AB - This review describes mechanisms of action of artemisinin-related antimalarials, emphasizing the site and target of activation, pathways of generating reactive species, and possible targets of free radicals with implications for antimalarial peroxide drug design. It also presents a useful link between the mode of action of artemisinin and that of chloroquine, and highlights redox cycles involved in the interaction between the drug and vital biomolecules.

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Mechanisms of in situ activation of peroxidic antimalarials

Abstract

ASJC Scopus subject areas

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