Mechanisms of NOD-like receptor-associated inflammasome activation

Haitao Wen, Edward A. Miao, Jenny P.Y. Ting

Research output: Contribution to journalReview articlepeer-review

319 Scopus citations

Abstract

A major function of a subfamily of NLR (nucleotide-binding domain, leucine-rich repeat containing, or NOD-like receptor) proteins is in inflammasome activation, which has been implicated in a multitude of disease models and human diseases. This work will highlight key progress in understanding the mechanisms that activate the best-studied NLRs (NLRP3, NLRC4, NAIP, and NLRP1) and in uncovering inflammasome NLRs.

Original languageEnglish (US)
Pages (from-to)432-441
Number of pages10
JournalImmunity
Volume39
Issue number3
DOIs
StatePublished - Sep 19 2013

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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