Mechanisms of retroviral mutation

Bradley D. Preston, Joseph P. Dougherty

Research output: Contribution to journalReview articlepeer-review

123 Scopus citations


Retroviruses, like other RNA viruses, mutate at very high rates (0.05-1 mutations per genome per replication cycle) and exist as complex genetically heterogeneous populations ('quasispecies') that are ever changing. De novo mutations are generated by inherently error-prone steps in the retroviral life cycle that introduce base substitutions, frame shifts, genetic rearrangements and hypermutations.

Original languageEnglish (US)
Pages (from-to)16-21
Number of pages6
JournalTrends in Microbiology
Issue number1
StatePublished - Jan 1996
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology


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