TY - JOUR
T1 - Mechanisms of retroviral mutation
AU - Preston, Bradley D.
AU - Dougherty, Joseph P.
N1 - Funding Information:
We are indebted to Howard Temin for his vision and inspiration over the years. He is deeplym issed. We also thank past and present members of our laboratories for valuable discussions and experimental contributions. Our research was supported by grants from the Leukemia Research Foundation, the Council for Tobacco Research, the American Cancer Society (JRFA-245), the March of Dimes (FY92-0699) and the National Institutes of Health (R01 AI34834 and R01 CA50777). B.D.P. was a Henry Rutgers Fellow and J.P.D. a Pew Foundation Scholar.
PY - 1996/1
Y1 - 1996/1
N2 - Retroviruses, like other RNA viruses, mutate at very high rates (0.05-1 mutations per genome per replication cycle) and exist as complex genetically heterogeneous populations ('quasispecies') that are ever changing. De novo mutations are generated by inherently error-prone steps in the retroviral life cycle that introduce base substitutions, frame shifts, genetic rearrangements and hypermutations.
AB - Retroviruses, like other RNA viruses, mutate at very high rates (0.05-1 mutations per genome per replication cycle) and exist as complex genetically heterogeneous populations ('quasispecies') that are ever changing. De novo mutations are generated by inherently error-prone steps in the retroviral life cycle that introduce base substitutions, frame shifts, genetic rearrangements and hypermutations.
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U2 - 10.1016/0966-842X(96)81500-9
DO - 10.1016/0966-842X(96)81500-9
M3 - Review article
C2 - 8824790
AN - SCOPUS:0030026763
SN - 0966-842X
VL - 4
SP - 16
EP - 21
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 1
ER -