Mechanisms of retroviral mutation

Bradley D. Preston, Joseph P. Dougherty

Research output: Contribution to journalReview articlepeer-review

117 Scopus citations

Abstract

Retroviruses, like other RNA viruses, mutate at very high rates (0.05-1 mutations per genome per replication cycle) and exist as complex genetically heterogeneous populations ('quasispecies') that are ever changing. De novo mutations are generated by inherently error-prone steps in the retroviral life cycle that introduce base substitutions, frame shifts, genetic rearrangements and hypermutations.

Original languageEnglish (US)
Pages (from-to)16-21
Number of pages6
JournalTrends in Microbiology
Volume4
Issue number1
DOIs
StatePublished - Jan 1996
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

Fingerprint

Dive into the research topics of 'Mechanisms of retroviral mutation'. Together they form a unique fingerprint.

Cite this