TY - JOUR
T1 - Mechanistic and functional shades of mucins and associated glycans in colon cancer
AU - Pothuraju, Ramesh
AU - Krishn, Shiv Ram
AU - Gautam, Shailendra K.
AU - Pai, Priya
AU - Ganguly, Koelina
AU - Chaudhary, Sanjib
AU - Rachagani, Satyanarayana
AU - Kaur, Sukhwinder
AU - Batra, Surinder K.
N1 - Funding Information:
Funding: The authors/work on this manuscript were supported, in part, by grants from the NIH (RO1 CA210637, RO1CA206444, RO1 CA183459, UO1 CA200466, R43CA235984, R44CA224619, P50 CA127297, and PO1 CA217798).
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/3
Y1 - 2020/3
N2 - Mucus serves as the chief protective barrier against pathogenic and mechanical insults in respiratory, gastrointestinal, and urogenital tracts. Altered mucin expression, the major component of mucus, in conjunction with differential glycosylation has been strongly associated with both benign and malignant pathologies of colon. Mucins and their associated glycans arbitrate their impact sterically as well as mechanically by altering molecular and microbial spectrum during pathogenesis. Mucin expression in normal and pathological conditions is regulated by nonspecific (dietary factors and gut microbiota) and specific (epigenetic and transcriptional) modulators. Further, recent studies highlight the impact of altering mucin glycome (cancer-associated carbohydrate antigens including Tn, Sialyl-Tn, Sialyl-Lew A, and Sialyl-Lewis X) on host immunomodulation, antitumor immunity, as well as gut microbiota. In light of emerging literature, the present review article digs into the impact of structural organization and of expressional and glycosylation alteration of mucin family members on benign and malignant pathologies of colorectal cancer.
AB - Mucus serves as the chief protective barrier against pathogenic and mechanical insults in respiratory, gastrointestinal, and urogenital tracts. Altered mucin expression, the major component of mucus, in conjunction with differential glycosylation has been strongly associated with both benign and malignant pathologies of colon. Mucins and their associated glycans arbitrate their impact sterically as well as mechanically by altering molecular and microbial spectrum during pathogenesis. Mucin expression in normal and pathological conditions is regulated by nonspecific (dietary factors and gut microbiota) and specific (epigenetic and transcriptional) modulators. Further, recent studies highlight the impact of altering mucin glycome (cancer-associated carbohydrate antigens including Tn, Sialyl-Tn, Sialyl-Lew A, and Sialyl-Lewis X) on host immunomodulation, antitumor immunity, as well as gut microbiota. In light of emerging literature, the present review article digs into the impact of structural organization and of expressional and glycosylation alteration of mucin family members on benign and malignant pathologies of colorectal cancer.
KW - Colon and colorectal cancer
KW - Glycans
KW - Inflammatory bowel disease
KW - MUC2
KW - MUC4
KW - MUC5AC
KW - Mucins
UR - http://www.scopus.com/inward/record.url?scp=85081210626&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85081210626&partnerID=8YFLogxK
U2 - 10.3390/cancers12030649
DO - 10.3390/cancers12030649
M3 - Review article
C2 - 32168759
AN - SCOPUS:85081210626
VL - 12
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 3
M1 - 649
ER -