Mechanistic and Therapeutic Approaches to Occupational Exposure-Associated Allergic and Non-Allergic Asthmatic Disease

Aaron D. Schwab, Jill A. Poole

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Purpose of Review: Occupational lung disease, including asthma, is a significant cause of disability worldwide. The dose, exposure frequency, and nature of the causal agent influence the inflammatory pathomechanisms that inform asthma disease phenotype and progression. While surveillance, systems engineering, and exposure mitigation strategies are essential preventative considerations, no targeted medical therapies are currently available to ameliorate lung injury post-exposure and prevent chronic airway disease development. Recent Findings: This article reviews contemporary understanding of allergic and non-allergic occupational asthma mechanisms. In addition, we discuss the available therapeutic options, patient-specific susceptibility and prevention measures, and recent scientific advances in post-exposure treatment conception. Summary: The course of occupational lung disease that follows exposure is informed by individual predisposition, immunobiologic response, agent identity, overall environmental risk, and preventative workplace practices. When protective strategies fail, knowledge of underlying disease mechanisms is necessary to inform targeted therapy development to lessen occupational asthma disease severity and occurrence.

Original languageEnglish (US)
Pages (from-to)313-324
Number of pages12
JournalCurrent allergy and asthma reports
Volume23
Issue number6
DOIs
StatePublished - Jun 2023

Keywords

  • Airway hyperresponsiveness
  • Allergy
  • Asthma
  • Immunotherapy
  • Inflammation
  • Occupational lung disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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