Mechanosensitive pathways are regulated by mechanosensitive miRNA clusters in endothelial cells

Sean Herault, Jarka Naser, Daniele Carassiti, K. Yean Chooi, Rosa Nikolopoulou, Marti Llopart Font, Miten Patel, Ryan Pedrigi, Rob Krams

Research output: Contribution to journalLetterpeer-review

1 Scopus citations

Abstract

Shear stress is known to affect many processes in (patho-) physiology through a complex, multi-molecular mechanism, termed mechanotransduction. The sheer complexity of the process has raised questions how mechanotransduction is regulated. Here, we comprehensively evaluate the literature about the role of small non-coding miRNA in the regulation of mechanotransduction. Regulation of mRNA by miRNA is rather complex, depending not only on the concentration of mRNA to miRNA, but also on the amount of mRNA competing for a single mRNA. The only mechanism to counteract the latter factor is through overarching structures of miRNA. Indeed, two overarching structures are present miRNA families and miRNA clusters, and both will be discussed in details, regarding the latest literature and a previous conducted study focussed on mechanotransduction. Both the literature and our own data support a new hypothesis that miRNA-clusters predominantly regulate mechanotransduction, affecting 65% of signalling pathways. In conclusion, a new and important mode of regulation of mechanotransduction is proposed, based on miRNA clusters. This finding implicates new avenues for treatment of mechanotransduction and atherosclerosis.

Original languageEnglish (US)
Pages (from-to)787-796
Number of pages10
JournalBiophysical Reviews
Volume13
Issue number5
DOIs
StatePublished - Oct 2021

Keywords

  • Laser capture
  • Mechanotransduction
  • miRNA families
  • Shear stress
  • Signalling pathways

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Molecular Biology

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