MECOM rearrangement involving the MYC locus: Two additional patients with the rare translocation, t(3;8)(q26.2;q24), and molecular review

Scott C. Smith, Tareq Z.S. Qdaisat, Pamela A. Althof, Bhavana J. Dave, Jennifer N. Sanmann

Research output: Contribution to journalArticlepeer-review

Abstract

A relatively small subset of myeloid neoplasms involve rearrangements of cytoband 3q26.2. Such rearrangements are often in response to therapy and carry a poor prognosis. The ectopic expression of MECOM is the result of such translocations. To date, thirty-three t(3;8)(q26.2;q24) cases have been reported; we contribute two patients with confirmed MECOM and MYC rearrangements. Both patients presented with pancytopenia and were diagnosed with myelodysplastic/myeloproliferative disorders. In addition to translocation t(3;8), Patient 1 possessed a derivative chromosome 5, while Patient 2 possessed monosomy 7; neither patient's clonal abnormalities resolved in follow-up studies. Of the previous 33 cases, one exhibited 5q loss, while monosomy 7 was found in fifteen. These findings contribute to the small number of reported cases with t(3;8) translocations. We also speculate about the molecular mechanisms associated with this translocation.

Original languageEnglish (US)
Article number106387
JournalLeukemia Research
Volume95
DOIs
StatePublished - Aug 2020

Keywords

  • MECOM rearrangement
  • MYC rearrangement
  • Myeloid neoplasms
  • t(3;8)(q26.2;q24)

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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