Mediation by catecholamines of the anticonvulsant activity of diazepam

G. J. Yutrzenka, S. S. Parmar, J. S. Davis

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The role of central catecholamines as mediators of the anticonvulsant activity of diazepam was investigated. Diazepam, administered in doses of 1 mg/kg and 2 mg/kg provided protection against pentylenetetrazol-induced convulsions in male, albino mice (CF1). Pretreatment with either reserpine, α-methyl-p-tyrosine, L-dopa, phenoxybenzamine or propranolol, prior to diazepam administration, potentiated the observed anticonvulsant activity of diazepam. On the other hand, pretreatment with disulfiram produced essentially no change in the anticonvulsant activity of diazepam. These results have provided evidence for the possible role of adrenergic pathways in the anticonvulsant activity of diazepam.

Original languageEnglish (US)
Pages (from-to)79-88
Number of pages10
JournalResearch Communications in Psychology, Psychiatry and Behavior
Volume4
Issue number1
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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