The role of central catecholamines as mediators of the anticonvulsant activity of diazepam was investigated. Diazepam, administered in doses of 1 mg/kg and 2 mg/kg provided protection against pentylenetetrazol-induced convulsions in male, albino mice (CF1). Pretreatment with either reserpine, α-methyl-p-tyrosine, L-dopa, phenoxybenzamine or propranolol, prior to diazepam administration, potentiated the observed anticonvulsant activity of diazepam. On the other hand, pretreatment with disulfiram produced essentially no change in the anticonvulsant activity of diazepam. These results have provided evidence for the possible role of adrenergic pathways in the anticonvulsant activity of diazepam.
|Original language||English (US)|
|Number of pages||10|
|Journal||Research Communications in Psychology, Psychiatry and Behavior|
|State||Published - 1979|
ASJC Scopus subject areas
- Psychiatry and Mental health