Medical Textiles as Substrates for Tissue Engineering

Sahar Salehi, Mahshid Kharaziha, Nafiseh Masoumi, Afsoon Fallahi, Ali Tamayol

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tissue engineering (TE) and regenerative medicine, with the aim to replace, repair and remodel the damaged tissues and organs, has led to development of myriad biomimetic materials that possess biomechanical properties resembling those of native tissues. Some of the key points to generate a successful replacement for native tissues are selecting the appropriate cell types and incorporating them into biomimetic three-dimensional (3D) scaffolds or substrates. Different types of biomaterials, including degradable or nondegradable materials with various morphologies and structures, can be used as scaffolds to provide a hospitable and supporting environment for cell growth and tissue regeneration. Fibrous scaffolds have been extensively used in regenerative medicine applications. Specifically, bio medical textiles with fibrous structure have a long history in treatment, repair, and replacement of tissues. While some applications are as simple as bandages or sutures, others are more complex like repair of heart valves, vascular grafts, and engineered skeletal muscle tissue. The fibrous structures/textiles can be devel oped in a way that their shapes and sizes match the tissue's or organ's structure or mechanics while enabling cellular infiltration due to their highly porous struc ture. In this chapter, we briefly discuss the fibrous structure applications in TE and regenerative medicine. Then, we review the background of medical textiles and summarize the fabrication methods for fibers and fibrous scaffolds with different morphologies and structures used in various TE applications (e.g. musculoskel etal, eye, cardiac, and nerve tissues). At the end, we highlight the future of medical textiles in regenerative medicine applications.

Original languageEnglish (US)
Title of host publicationTextile Finishing
Subtitle of host publicationRecent Developments and Future Trends
PublisherWiley-Blackwell
Pages363-421
Number of pages59
ISBN (Electronic)9781119426790
ISBN (Print)9781119426769
DOIs
StatePublished - Sep 1 2017

Keywords

  • Fibrous scaffolds biodegradable polymers 3D scaffolds
  • Medical textiles
  • Tissue engineering

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)

Fingerprint Dive into the research topics of 'Medical Textiles as Substrates for Tissue Engineering'. Together they form a unique fingerprint.

  • Cite this

    Salehi, S., Kharaziha, M., Masoumi, N., Fallahi, A., & Tamayol, A. (2017). Medical Textiles as Substrates for Tissue Engineering. In Textile Finishing: Recent Developments and Future Trends (pp. 363-421). Wiley-Blackwell. https://doi.org/10.1002/9781119426790.ch11