Medicinal chemistry and brain drug penetrance

James Hilaire, Howard E. Gendelman

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recent advances in molecular neuroscience and neuropharmacology have improved our knowledge of the intricate mechanisms that define and treat infectious, immune and degenerative disorders of the brain and spinal cord. As our knowledge expands, treatment of central nervous system diseases still remains a challenge. One obstacle is drug delivery. Indeed, designed to protect the brain from toxic molecules, the blood-brain barrier also limits therapeutic drug entry into the brain. The dynamic balance between the exclusion and therapeutic delivery remains a key component to improve disease outcomes.

Original languageEnglish (US)
Title of host publicationNeuroimmune Pharmacology
PublisherSpringer International Publishing
Pages831-845
Number of pages15
ISBN (Electronic)9783319440224
ISBN (Print)9783319440200
DOIs
StatePublished - Jan 1 2016

Keywords

  • Blood-brain barrier
  • Carrier-mediated transport
  • Central nervous system
  • GLUT1
  • LAT1
  • Lipidization
  • Prodrugs

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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