Medicinal chemistry and brain drug penetrance

James Hilaire; Howard E. Gendelman

doi:10.1007/978-3-319-44022-4_49

Medicinal chemistry and brain drug penetrance

James Hilaire, Howard E. Gendelman

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Recent advances in molecular neuroscience and neuropharmacology have improved our knowledge of the intricate mechanisms that define and treat infectious, immune and degenerative disorders of the brain and spinal cord. As our knowledge expands, treatment of central nervous system diseases still remains a challenge. One obstacle is drug delivery. Indeed, designed to protect the brain from toxic molecules, the blood-brain barrier also limits therapeutic drug entry into the brain. The dynamic balance between the exclusion and therapeutic delivery remains a key component to improve disease outcomes.

Original language	English (US)
Title of host publication	Neuroimmune Pharmacology
Publisher	Springer International Publishing
Pages	831-845
Number of pages	15
ISBN (Electronic)	9783319440224
ISBN (Print)	9783319440200
DOIs	https://doi.org/10.1007/978-3-319-44022-4_49
State	Published - Jan 1 2016

Keywords

Blood-brain barrier
Carrier-mediated transport
Central nervous system
GLUT1
LAT1
Lipidization
Prodrugs

ASJC Scopus subject areas

General Medicine
General Immunology and Microbiology
General Neuroscience
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1007/978-3-319-44022-4_49

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Medicinal chemistry and brain drug penetrance

Abstract

Keywords

ASJC Scopus subject areas

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