Recent advances in molecular neuroscience and neuropharmacology have improved our knowledge of the intricate mechanisms that define and treat infectious, immune and degenerative disorders of the brain and spinal cord. As our knowledge expands, treatment of central nervous system diseases still remains a challenge. One obstacle is drug delivery. Indeed, designed to protect the brain from toxic molecules, the blood-brain barrier also limits therapeutic drug entry into the brain. The dynamic balance between the exclusion and therapeutic delivery remains a key component to improve disease outcomes.
- Blood-brain barrier
- Carrier-mediated transport
- Central nervous system
ASJC Scopus subject areas
- Immunology and Microbiology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)