Medicinal chemistry and brain drug penetrance

James Hilaire, Howard E. Gendelman

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Recent advances in molecular neuroscience and neuropharmacology have improved our knowledge of the intricate mechanisms that define and treat infectious, immune and degenerative disorders of the brain and spinal cord. As our knowledge expands, treatment of central nervous system diseases still remains a challenge. One obstacle is drug delivery. Indeed, designed to protect the brain from toxic molecules, the blood-brain barrier also limits therapeutic drug entry into the brain. The dynamic balance between the exclusion and therapeutic delivery remains a key component to improve disease outcomes.

Original languageEnglish (US)
Title of host publicationNeuroimmune Pharmacology
PublisherSpringer International Publishing
Number of pages15
ISBN (Electronic)9783319440224
ISBN (Print)9783319440200
StatePublished - Jan 1 2016


  • Blood-brain barrier
  • Carrier-mediated transport
  • Central nervous system
  • GLUT1
  • LAT1
  • Lipidization
  • Prodrugs

ASJC Scopus subject areas

  • General Medicine
  • General Immunology and Microbiology
  • General Neuroscience
  • Pharmacology, Toxicology and Pharmaceutics(all)


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