Meeting report of the STAR—Sensitization in Transplantation Assessment of Risk: Naïve Abdominal Transplant Organ subgroup focus on kidney transplantation

Roslyn B. Mannon, Medhat Askar, Annette M. Jackson, Kenneth Newell, Michael Mengel

Research output: Contribution to journalArticle

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Abstract

The development of de novo donor-specific HLA antibody (dnDSA) is a critical feature contributing to late allograft failure. The complexity of the issue is further complicated by organ-specific differences, detection techniques, reliance of tissue histopathology and changing diagnostic criteria, ineffective therapies, and lack of consensus. To tackle these issues, the Sensitization in Transplantation Assessment of Risk (STAR) 2017 was initiated as a collaboration of the American Society of Transplantation and American Society of Histocompatibility and Immunogenetics consisting of 8 working groups with the goal to provide guidelines on how to assess risk and risk stratify patients based on their potential alloimmune and DSA status. Herein is a summary of discussions by the Naïve Abdominal Working Group, highlighting currently available data and identifying gaps in our knowledge on the development and impact of dnDSA following kidney transplantation.

Original languageEnglish (US)
Pages (from-to)2120-2134
Number of pages15
JournalAmerican Journal of Transplantation
Volume18
Issue number9
DOIs
StatePublished - Sep 2018

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Keywords

  • alloantibody
  • clinical research/practice
  • crossmatch
  • graft survival
  • kidney failure/injury
  • kidney transplantation/nephrology
  • rejection: antibody-mediated (ABMR)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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