Melanopsin signaling and nonvisual ocular photoreception

Sowmya V. Yelamanchili, Victoria Piamonte, Surendra Kumar Nayak, Nobushige Tanaka, Quansheng Zhu, Kacee Jones, Hiep Le, Satchidananda Panda

Research output: Chapter in Book/Report/Conference proceedingChapter


Organisms, ranging from cyanobacteria to mammals, use an intrinsic circadian clock and photosensors to regulate behavior and physiology in resonance with geophysical time. In mammals, an endogenous master clock functions in the suprachiasmatic nuclei (SCN) of the hypothalamus, and is entrained to the day-night cycle by direct light input from the retina. Appropriate photoentrainment is essential for general health, as shift work and similar chronic circadian desynchronization have been shown to be major risk factors in several sleep disorders, metabolic syndromes, and in cancer (reviewed in (1)). Understanding the molecular processes underlying photoentrainment will therefore help identify new strategies and targets for therapeutic intervention in these disorders.

Original languageEnglish (US)
Title of host publicationSignal Transduction in the Retina
PublisherCRC Press
Number of pages28
ISBN (Electronic)9781420007169
ISBN (Print)9780849373152
StatePublished - Jan 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Neuroscience
  • General Medicine


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