Membrane properties of retinal stem cells/progenitors

Ani V. Das; Sreekumaran Edakkot; Wallace B. Thoreson; Jackson James; Sumitra Bhattacharya; Iqbal Ahmad

doi:10.1016/j.preteyeres.2005.04.003

Membrane properties of retinal stem cells/progenitors

Ani V. Das, Sreekumaran Edakkot, Wallace B. Thoreson, Jackson James, Sumitra Bhattacharya, Iqbal Ahmad

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

The membrane properties of cells help integrate extrinsic information relayed through growth factors, chemokines, extracellular matrix, gap junctions and neurotransmitters towards modulating cell-intrinsic properties, which in turn determine whether cells remain quiescent, proliferate, differentiate, establish contact with other cells or remove themselves by activating programmed cell death. This review highlights some of the membrane properties of early and late retinal stem cells/progenitors, which are likely to be helpful in the identification and enrichment of these cells and in understanding mechanisms underlying their maintenance and differentiation. Understanding of membrane properties of retinal stem cells/progenitors is essential for the successful formulation of approaches to treat retinal degeneration and diseases by cell therapy.

Original language	English (US)
Pages (from-to)	663-681
Number of pages	19
Journal	Progress in Retinal and Eye Research
Volume	24
Issue number	6
DOIs	https://doi.org/10.1016/j.preteyeres.2005.04.003
State	Published - Nov 2005

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

Access to Document

10.1016/j.preteyeres.2005.04.003

Cite this

@article{bc586398594b48d2a07e3f013598f915,

title = "Membrane properties of retinal stem cells/progenitors",

abstract = "The membrane properties of cells help integrate extrinsic information relayed through growth factors, chemokines, extracellular matrix, gap junctions and neurotransmitters towards modulating cell-intrinsic properties, which in turn determine whether cells remain quiescent, proliferate, differentiate, establish contact with other cells or remove themselves by activating programmed cell death. This review highlights some of the membrane properties of early and late retinal stem cells/progenitors, which are likely to be helpful in the identification and enrichment of these cells and in understanding mechanisms underlying their maintenance and differentiation. Understanding of membrane properties of retinal stem cells/progenitors is essential for the successful formulation of approaches to treat retinal degeneration and diseases by cell therapy.",

author = "Das, {Ani V.} and Sreekumaran Edakkot and Thoreson, {Wallace B.} and Jackson James and Sumitra Bhattacharya and Iqbal Ahmad",

note = "Funding Information: This work is supported by NEI (IA) and Research to Prevent Blindness.",

year = "2005",

month = nov,

doi = "10.1016/j.preteyeres.2005.04.003",

language = "English (US)",

volume = "24",

pages = "663--681",

journal = "Progress in Retinal and Eye Research",

issn = "1350-9462",

publisher = "Elsevier Ltd",

number = "6",

}

TY - JOUR

T1 - Membrane properties of retinal stem cells/progenitors

AU - Das, Ani V.

AU - Edakkot, Sreekumaran

AU - Thoreson, Wallace B.

AU - James, Jackson

AU - Bhattacharya, Sumitra

AU - Ahmad, Iqbal

N1 - Funding Information: This work is supported by NEI (IA) and Research to Prevent Blindness.

PY - 2005/11

Y1 - 2005/11

N2 - The membrane properties of cells help integrate extrinsic information relayed through growth factors, chemokines, extracellular matrix, gap junctions and neurotransmitters towards modulating cell-intrinsic properties, which in turn determine whether cells remain quiescent, proliferate, differentiate, establish contact with other cells or remove themselves by activating programmed cell death. This review highlights some of the membrane properties of early and late retinal stem cells/progenitors, which are likely to be helpful in the identification and enrichment of these cells and in understanding mechanisms underlying their maintenance and differentiation. Understanding of membrane properties of retinal stem cells/progenitors is essential for the successful formulation of approaches to treat retinal degeneration and diseases by cell therapy.

AB - The membrane properties of cells help integrate extrinsic information relayed through growth factors, chemokines, extracellular matrix, gap junctions and neurotransmitters towards modulating cell-intrinsic properties, which in turn determine whether cells remain quiescent, proliferate, differentiate, establish contact with other cells or remove themselves by activating programmed cell death. This review highlights some of the membrane properties of early and late retinal stem cells/progenitors, which are likely to be helpful in the identification and enrichment of these cells and in understanding mechanisms underlying their maintenance and differentiation. Understanding of membrane properties of retinal stem cells/progenitors is essential for the successful formulation of approaches to treat retinal degeneration and diseases by cell therapy.

UR - http://www.scopus.com/inward/record.url?scp=24344440171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24344440171&partnerID=8YFLogxK

U2 - 10.1016/j.preteyeres.2005.04.003

DO - 10.1016/j.preteyeres.2005.04.003

M3 - Review article

C2 - 15939659

AN - SCOPUS:24344440171

SN - 1350-9462

VL - 24

SP - 663

EP - 681

JO - Progress in Retinal and Eye Research

JF - Progress in Retinal and Eye Research

IS - 6

ER -

Membrane properties of retinal stem cells/progenitors

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this