Membrane properties of retinal stem cells/progenitors

Ani V. Das, Sreekumaran Edakkot, Wallace B. Thoreson, Jackson James, Sumitra Bhattacharya, Iqbal Ahmad

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

The membrane properties of cells help integrate extrinsic information relayed through growth factors, chemokines, extracellular matrix, gap junctions and neurotransmitters towards modulating cell-intrinsic properties, which in turn determine whether cells remain quiescent, proliferate, differentiate, establish contact with other cells or remove themselves by activating programmed cell death. This review highlights some of the membrane properties of early and late retinal stem cells/progenitors, which are likely to be helpful in the identification and enrichment of these cells and in understanding mechanisms underlying their maintenance and differentiation. Understanding of membrane properties of retinal stem cells/progenitors is essential for the successful formulation of approaches to treat retinal degeneration and diseases by cell therapy.

Original languageEnglish (US)
Pages (from-to)663-681
Number of pages19
JournalProgress in Retinal and Eye Research
Volume24
Issue number6
DOIs
StatePublished - Nov 2005

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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