Merrifield MicroTube(TM) reactors for solid phase synthesis

Rongshi Li, Xiao Yi Xiao, Anthony W. Czarnik

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Polystyrene grafted polypropylene MicroTube(TM) reactors (length x OD, 25 x 5 mm) have been functionalized with chloromethyl groups (Merrifield- type) using chloromethyl methyl ether and Lewis acid catalysts. A potentiometric method using a chloride ion selective electrode has been developed to measure the loading of the Merrifield MicroTube(TM) reactors. A typical loading of 25-35 μmol/tube for Merrifield MicroTube(TM) reactors has been achieved. Several reactions performed on Merrifield MicroTube(TM) reactors demonstrated that they are excellent supports for solid phase synthesis. As a result of the ease with which radiofrequency memory tags can be associated with and separated from the supports, these MicroTube(TM) reactors can facilitate the synthesis of combinatorial libraries.

Original languageEnglish (US)
Pages (from-to)8581-8584
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number47
DOIs
StatePublished - Nov 19 1998

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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