Mesenchymal stem cell-based therapy

Vaibhav Mundra, Ivan C. Gerling, Ram I. Mahato

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

Mesenchymal stem cells (MSCs) are multipotent adult stem cells which have self-renewal capacity and differentiation potential into several mesenchymal lineages including bones, cartilages, adipose tissues and tendons. MSCs may repair tissue injuries and prevent immune cell activation and proliferation. Immunomodulation and secretion of growth factors by MSCs have led to realizing the true potential of MSC-based cell therapy. The use of MSCs as immunomodulators has been explored in cell/organ transplant, tissue repair, autoimmune diseases, and prevention of graft vs host disease (GVHD). This review focuses on the clinical applications of MSC-based cell therapy, with particular emphasis on islet transplantation for treating type I diabetes.

Original languageEnglish (US)
Pages (from-to)77-89
Number of pages13
JournalMolecular Pharmaceutics
Volume10
Issue number1
DOIs
StatePublished - Jan 7 2013

Keywords

  • biomaterials
  • gene delivery
  • immunomodulation
  • islet transplantation
  • mesenchymal stem cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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