Mesenchymal tumors of the mouse urinary bladder with vascular and smooth muscle differentiation

William H. Butler, Samuel H. Cohen, Robert A. Squire

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Bifenthrin, a synthetic pyrethroid insecticide/miticide, has been fed to male and female Swiss Webster mice at levels of 0.50, 200, 500, and 600 ppm in the diet for between 604 and 644 days. Tumors of the urinary bladder were observed and initially reported as leiomyosarcomas. Subsequently, the bladders were reviewed and the tumors showed a pattern of both epithelioid cells anti spindle cells forming irregular vascular channels. The tumors appeared to arise from the trigone of the bladder and, in some cases, invaded the bladder wall. No metastases were recorded. The tumor is usually considered rare; however, in this study, it was commonly observed in all groups but predominantly in males. The histogenesis of the tumor is uncertain, but from its pleomorphic histological features, including smooth muscle and vascularity, it is probably derived from vascular mesenchyme.

Original languageEnglish (US)
Pages (from-to)268-274
Number of pages7
JournalToxicologic Pathology
Issue number3
StatePublished - 1997


  • Bifenthrin
  • Insecticide
  • Miticide

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Toxicology
  • Cell Biology


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