Abstract
Meta-analyses guide planning of clinical trials and clinical care, but are subject to all the methodologic problems and potential biases present in the underlying trials. Furthermore, publication bias often contributes to overestimated benefit in meta-analyses of small trials, which are often ‘corrected’ by subsequent large trials. Meta-analyses are no substitute for large robust trials.
Original language | English (US) |
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Pages (from-to) | 233-235 |
Number of pages | 3 |
Journal | British Journal of Anaesthesia |
Volume | 128 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2022 |
Keywords
- anaesthesia
- bias
- clinical trial methodology
- meta-analysis
- outcomes
- postoperative pulmonary complications
- rigour
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine