Meta-analyses of clinical trials: are we getting lemonade from lemons?

Karsten Bartels; Daniel I. Sessler

doi:10.1016/j.bja.2021.09.028

Meta-analyses of clinical trials: are we getting lemonade from lemons?

Karsten Bartels, Daniel I. Sessler

Anesthesiology

Research output: Contribution to journal › Editorial › peer-review

8 Scopus citations

Abstract

Meta-analyses guide planning of clinical trials and clinical care, but are subject to all the methodologic problems and potential biases present in the underlying trials. Furthermore, publication bias often contributes to overestimated benefit in meta-analyses of small trials, which are often ‘corrected’ by subsequent large trials. Meta-analyses are no substitute for large robust trials.

Original language	English (US)
Pages (from-to)	233-235
Number of pages	3
Journal	British Journal of Anaesthesia
Volume	128
Issue number	2
DOIs	https://doi.org/10.1016/j.bja.2021.09.028
State	Published - Feb 2022

Keywords

anaesthesia
bias
clinical trial methodology
meta-analysis
outcomes
postoperative pulmonary complications
rigour

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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10.1016/j.bja.2021.09.028

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abstract = "Meta-analyses guide planning of clinical trials and clinical care, but are subject to all the methodologic problems and potential biases present in the underlying trials. Furthermore, publication bias often contributes to overestimated benefit in meta-analyses of small trials, which are often {\textquoteleft}corrected{\textquoteright} by subsequent large trials. Meta-analyses are no substitute for large robust trials.",

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KW - outcomes

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KW - rigour

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Meta-analyses of clinical trials: are we getting lemonade from lemons?

Abstract

Keywords

ASJC Scopus subject areas

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