Metabolic liver disease in the young adult

Mark E. Mailliard, John L. Gollan

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

This chapter describes the gene mutations, phenotypes, diagnosis and therapy of the common metabolic liver diseases in young adulthood: haemochromatosis, Wilson disease, α1- anti-trypsin deficiency and cystic fibrosis. The remarkable variability of the phenotypical expression of the mutated genotypes makes screening recommendations and the establishment of prognosis for these liver disorders in young adults problematical. The diagnosis and therapy of the young adult with metabolic liver disease is discussed, with an emphasis on maintaining quality-of-life and balancing the importance of early intervention with the stigmatization of the diagnosis of potentially life-threatening liver disease. There is a critical need for the development of biochemical markers that would predict the risk of expression of clinical phenotypes and prognosis.

Original languageEnglish (US)
Pages (from-to)307-322
Number of pages16
JournalBailliere's Best Practice and Research in Clinical Gastroenterology
Volume17
Issue number2
DOIs
StatePublished - Apr 2003

Keywords

  • Cystic fibrosis
  • Haemochromatosis
  • Liver disease
  • Wilson disease
  • α- anti-trypsin

ASJC Scopus subject areas

  • Gastroenterology

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