Metabolic Regulation of Macrophage Polarization in Cancer

Kamiya Mehla; Pankaj K. Singh

doi:10.1016/j.trecan.2019.10.007

Metabolic Regulation of Macrophage Polarization in Cancer

Kamiya Mehla, Pankaj K. Singh

Research output: Contribution to journal › Review article › peer-review

373 Scopus citations

Abstract

Macrophages act as scavengers, modulating the immune response against pathogens and maintaining tissue homeostasis. Metabolism governs macrophage differentiation, polarization, mobilization, and the ability to mount an effective antitumor response. However, in cancer, the tumor microenvironment (TME) can actively reprogram macrophage metabolism either by direct exchange of metabolites or through cytokines and other signaling mediators. Thus, metabolic reprogramming holds potential for modulating macrophages and developing new therapeutic approaches. In this review, we provide an overview of macrophage metabolism as it relates to macrophage function and plasticity in cancer.

Original language	English (US)
Pages (from-to)	822-834
Number of pages	13
Journal	Trends in Cancer
Volume	5
Issue number	12
DOIs	https://doi.org/10.1016/j.trecan.2019.10.007
State	Published - Dec 2019

Keywords

M1–M2 macrophage polarization
MUC1
cancer
immunometabolism
metabolic reprogramming
tumor microenvironment
tumor-associated macrophages

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.trecan.2019.10.007

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title = "Metabolic Regulation of Macrophage Polarization in Cancer",

abstract = "Macrophages act as scavengers, modulating the immune response against pathogens and maintaining tissue homeostasis. Metabolism governs macrophage differentiation, polarization, mobilization, and the ability to mount an effective antitumor response. However, in cancer, the tumor microenvironment (TME) can actively reprogram macrophage metabolism either by direct exchange of metabolites or through cytokines and other signaling mediators. Thus, metabolic reprogramming holds potential for modulating macrophages and developing new therapeutic approaches. In this review, we provide an overview of macrophage metabolism as it relates to macrophage function and plasticity in cancer.",

keywords = "M1–M2 macrophage polarization, MUC1, cancer, immunometabolism, metabolic reprogramming, tumor microenvironment, tumor-associated macrophages",

author = "Kamiya Mehla and Singh, {Pankaj K.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

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doi = "10.1016/j.trecan.2019.10.007",

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AU - Singh, Pankaj K.

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AB - Macrophages act as scavengers, modulating the immune response against pathogens and maintaining tissue homeostasis. Metabolism governs macrophage differentiation, polarization, mobilization, and the ability to mount an effective antitumor response. However, in cancer, the tumor microenvironment (TME) can actively reprogram macrophage metabolism either by direct exchange of metabolites or through cytokines and other signaling mediators. Thus, metabolic reprogramming holds potential for modulating macrophages and developing new therapeutic approaches. In this review, we provide an overview of macrophage metabolism as it relates to macrophage function and plasticity in cancer.

KW - M1–M2 macrophage polarization

KW - MUC1

KW - cancer

KW - immunometabolism

KW - metabolic reprogramming

KW - tumor microenvironment

KW - tumor-associated macrophages

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JO - Trends in Cancer

JF - Trends in Cancer

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Metabolic Regulation of Macrophage Polarization in Cancer

Abstract

Keywords

ASJC Scopus subject areas

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