Metabolic Regulation of Macrophage Polarization in Cancer

Kamiya Mehla, Pankaj K. Singh

Research output: Contribution to journalReview articlepeer-review

266 Scopus citations


Macrophages act as scavengers, modulating the immune response against pathogens and maintaining tissue homeostasis. Metabolism governs macrophage differentiation, polarization, mobilization, and the ability to mount an effective antitumor response. However, in cancer, the tumor microenvironment (TME) can actively reprogram macrophage metabolism either by direct exchange of metabolites or through cytokines and other signaling mediators. Thus, metabolic reprogramming holds potential for modulating macrophages and developing new therapeutic approaches. In this review, we provide an overview of macrophage metabolism as it relates to macrophage function and plasticity in cancer.

Original languageEnglish (US)
Pages (from-to)822-834
Number of pages13
JournalTrends in Cancer
Issue number12
StatePublished - Dec 2019


  • M1–M2 macrophage polarization
  • MUC1
  • cancer
  • immunometabolism
  • metabolic reprogramming
  • tumor microenvironment
  • tumor-associated macrophages

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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