Metabolism of Arylhydrazines by Mouse Liver Mixed-Function Oxidases in Vitro

Terence Lawson, Yeshpal Chauhan

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The metabolism of a group of arylhydrazines and arylhydrazides by mouse liver mixed-function oxidases was studied in vitro. The arylhydrazines, 4-methylphenylhydrazine hydrochloride and the N-acetyl derivatives of 4-methylphenyl-and 4-(hydroxymethyl)phenylhydrazine, were all readily metabolized. Their metabolism was inhibited by metyrapone and carbon monoxide. Agaritine, the arylhydrazide [Nβ-[(+)-γ-glutamyl]-4-(hydroxymethyl)phenylhydrazine] (A), was poorly metabolized. The small amount of metabolism of A was not inhibited by metyrapone or carbon monoxide, suggesting that the breakdown represented nonspecific decomposition, not metabolism.

Original languageEnglish (US)
Pages (from-to)218-219
Number of pages2
JournalJournal of Agricultural and Food Chemistry
Volume33
Issue number2
DOIs
StatePublished - Mar 1985

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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