Metabolome analysis

Camila Pereira Braga, Jiri Adamec

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Metabolomics was most recently introduced among the Omics to analyze low molecular weight compounds in different biological systems and fields of research. Metabolomics analysis can be categorized into two approaches, targeted and untargeted metabolomics. In targeted metabolomics, the metabolites selected for quantification are known a priori, as defined by the biological problem and may represent specific pathway or class of molecules. Untargeted metabolomics, on the other hand, is used to determine as many metabolites as possible and involves both metabolites quantification and their identification. The aim of this article is to review the steps in metabolomics analysis, starting with sample preparation through metabolite identification and data interpretation, and to discuss, as well, the applications of metabolomics in different fields.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Bioinformatics and Computational Biology
Subtitle of host publicationABC of Bioinformatics
PublisherElsevier
Pages463-475
Number of pages13
Volume1-3
ISBN (Electronic)9780128114322
ISBN (Print)9780128114148
DOIs
StatePublished - Jan 1 2018

Keywords

  • Biomarkers
  • Metabolites
  • Metabolomics
  • Pathway
  • Profiling

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Braga, C. P., & Adamec, J. (2018). Metabolome analysis. In Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics (Vol. 1-3, pp. 463-475). Elsevier. https://doi.org/10.1016/B978-0-12-809633-8.20134-9