Metastasis suppressors and the tumor microenvironment

Leah M. Cook, Douglas R. Hurst, Danny R. Welch

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


The most lethal and debilitating attribute of cancer cells is their ability to metastasize. Throughout the process of metastasis, tumor cells interact with other tumor cells, host cells and a variety of molecules. Tumor cells are also faced with a number of insults, such as hemodynamic sheer pressure and immune selection. This brief review explores how metastasis suppressor proteins regulate interactions between tumor cells and the microenvironments in which tumor cells find themselves.

Original languageEnglish (US)
Pages (from-to)113-122
Number of pages10
JournalSeminars in Cancer Biology
Issue number2
StatePublished - Apr 2011
Externally publishedYes


  • Angiogenesis
  • BRMS1
  • CD44
  • Caspase 8
  • DLC1
  • DRG1
  • E-cadherin
  • Gelsolin
  • HUNK
  • JNKK1/MKK7/p38
  • KAI1
  • KISS1
  • Kisspeptin
  • LSD1
  • Nm23
  • OGR1
  • RECK
  • Review
  • RhoGDI2
  • Ribonucleotide reductase M1
  • SseCKS/Gravin/AKAP12
  • TIMP

ASJC Scopus subject areas

  • Cancer Research


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