Method development for separating organic carbonates by ion-moderated high-performance liquid chromatography

Anuja Bhalkikar, Chris M. Marin, Chin Li Cheung

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


An ion-moderated partition high-performance liquid chromatography method was developed for the separation and identification of common organic carbonates. The separation of organic carbonates was achieved on an ion exclusion column with an exchangeable hydrogen ion. An isocratic, aqueous mobile phase was used for elution and detection was performed with a refractive index detector. The developed method was validated for specificity, linearity, limits of detection and quantification, precision and accuracy. All calibration curves showed excellent linear regression (R2 > 0.9990) within the testing range. The limits of detection were 3.8–30.8 ppm for the analyzed carbonates. Improvements in the peak resolution of the chromatograms were achieved by decreasing the column temperature. Addition of the organic modifier, acetonitrile, to the eluent was found to have insignificant effects on the peak resolution. The developed method was demonstrated for analyzing organic carbonate components in the electrolyte system of a commercial lithium ion battery.

Original languageEnglish (US)
Pages (from-to)4484-4491
Number of pages8
JournalJournal of Separation Science
Issue number23
StatePublished - Dec 1 2016


  • High-performance liquid chromatography
  • Lithium ion batteries
  • Method development
  • Organic carbonates

ASJC Scopus subject areas

  • Analytical Chemistry
  • Filtration and Separation


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