Methods for evaluating the lung in human subjects

Stephen I. Rennard, John R. Spurzen

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The lung is frequently the target of environmental and systemic toxic exposures. A normal adult at rest takes in more than 7000 l of air daily (1). Gas exchange requires exposure of a surface area of approximately 80 m of the lung to this inhaled air (2). This makes the lung uniquely exposed to airborne toxins. In addition, the lung receives the entire cardiac output from the right side of the heart, which places it at risk for systemic toxins. Finally, specific metabolic reactions in the lung can lead to the uptake and concentration of a variety of toxins in the lung. As a result, toxic exposures are a frequent cause of lung disease. Evaluation of the lung, therefore, is highly relevant in toxicological studies.

Original languageEnglish (US)
Title of host publicationToxicology of the Lung, Fourth Edition
PublisherCRC Press
Pages1-28
Number of pages28
ISBN (Electronic)9781616310202
ISBN (Print)9780849328350
StatePublished - Jan 1 2005

ASJC Scopus subject areas

  • Medicine(all)
  • Environmental Science(all)

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