Methylation of hamster DNA by the carcinogen N-nitroso-bis (2-oxopropyl)amine

T. A. Lawson, R. Gingell, D. Nagel, L. A. Hines, A. Ross

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50 Scopus citations

Abstract

The alkylation of hamster liver, lung and pancreas DNA by [1-14C]- and [2,3-14C]N-nitrosobis (2-oxopropyl) amine (BOP) has been examined. The specific activity of pancreas DNA after [2,3-14C]BOP administration was only 2% of that when [1-14C]BOP was given. 7-Methylguanine, but not O-6-methylguanine, was found in hydrolysates of liver and pancreas DNA. Nearly equal amounts of alkylation were produced in the liver when [1-14C]- and [2,3-14C]BOP were given. At least one-half of the radioactivity in the liver was associated with N-alkylated purines, whereas only 20% was in this form in the pancreas.

Original languageEnglish (US)
Pages (from-to)251-255
Number of pages5
JournalCancer Letters
Volume11
Issue number3
DOIs
StatePublished - Jan 1981

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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