Microbiota, oral microbiome, and pancreatic cancer

Dominique S. Michaud, Jacques Izard

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations

Abstract

Only 30% of patients with a diagnosis of pancreatic cancer survive 1 year after the diagnosis. Progress in understanding the causes of pancreatic cancer has been made, including solidifying the associations with obesity and diabetes, and a proportion of cases should be preventable through lifestyle modifications. Unfortunately, identifying reliable biomarkers of early pancreatic cancer has been extremely challenging, and no effective screening modality is currently available for this devastating form of cancer. Recent data suggest that the microbiota may play a role in the disease process, but many questions remain. Future studies focusing on the human microbiome, both etiologically and as a marker of disease susceptibility, should shed light on how to better tackle prevention, early detection, and treatment of this highly fatal disease.

Original languageEnglish (US)
Pages (from-to)203-206
Number of pages4
JournalCancer Journal (United States)
Volume20
Issue number3
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Periodontitis
  • digestive tract
  • inflammation
  • pancreas

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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