@inproceedings{6c2a70d6201e46619fa697c0f8cbc677,
title = "Microfluidic gradient generator for drug screening applications",
abstract = "Generating chemical and mechanical gradients in a single microfluidic chip is one of key requirements for high throughput biological assays. In this study, we developed two different microfluidic gradient generator designs that are capable of simultaneous in vitro cell culturing and screening of the synergic effect of the chemical and mechanical gradients. Both designs produce the desired chemical gradients, and the fluid flow introduces the mechanical stimuli gradient over the cultured cells. We demonstrated the effectiveness of these devices by culturing two different cell lines and studied their responses to chemical and mechanical gradients.",
keywords = "Drug screening, Gradient generation, High throughput, Microfluidics, Shear stress",
author = "Arian Jaberi and Esfahani, {Amir Monemian} and Ali Tamayol and Ruiguo Yang",
note = "Publisher Copyright: {\textcopyright} 2020 CBMS-0001; 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 ; Conference date: 04-10-2020 Through 09-10-2020",
year = "2020",
language = "English (US)",
series = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "1234--1235",
booktitle = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
}