Microfluidic gradient generator for drug screening applications

Arian Jaberi, Amir Monemian Esfahani, Ali Tamayol, Ruiguo Yang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Generating chemical and mechanical gradients in a single microfluidic chip is one of key requirements for high throughput biological assays. In this study, we developed two different microfluidic gradient generator designs that are capable of simultaneous in vitro cell culturing and screening of the synergic effect of the chemical and mechanical gradients. Both designs produce the desired chemical gradients, and the fluid flow introduces the mechanical stimuli gradient over the cultured cells. We demonstrated the effectiveness of these devices by culturing two different cell lines and studied their responses to chemical and mechanical gradients.

Original languageEnglish (US)
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1234-1235
Number of pages2
ISBN (Electronic)9781733419017
StatePublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: Oct 4 2020Oct 9 2020

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period10/4/2010/9/20

Keywords

  • Drug screening
  • Gradient generation
  • High throughput
  • Microfluidics
  • Shear stress

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering
  • Chemistry(all)
  • Control and Systems Engineering

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