Microglia: Friends or Foes in Glaucoma? A Developmental Perspective

Iqbal Ahmad, Murali Subramani

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Glaucoma is the most prevalent form of optic neuropathy where a progressive degeneration of retinal ganglion cells (RGCs) leads to irreversible loss of vision. The mechanism underlying glaucomatous degeneration remains poorly understood. However, evidence suggests that microglia, which regulate RGC numbers and synaptic integrity during development and provide homeostatic support in adults, may contribute to the disease process. Hence, microglia represent a valid cellular target for therapeutic approaches in glaucoma. Here, we provide an overview of the role of microglia in RGC development and degeneration in the backdrop of neurogenesis and neurodegeneration in the central nervous system and discuss how pathological recapitulation of microglia-mediated developmental mechanisms may help initiate or exacerbate glaucomatous degeneration.

Original languageEnglish (US)
Pages (from-to)1210-1218
Number of pages9
JournalStem Cells Translational Medicine
Issue number12
StatePublished - Dec 2022


  • degeneration
  • glaucoma
  • microglia
  • neurogenesis
  • retinal ganglion cell

ASJC Scopus subject areas

  • General Medicine


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