MicroRNA-1: Diverse role of a small player in multiple cancers

Parvez Khan, Nivetha Sarah Ebenezer, Jawed Akhtar Siddiqui, Shailendra Kumar Maurya, Imayavaramban Lakshmanan, Ravi Salgia, Surinder Kumar Batra, Mohd Wasim Nasser

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


The process of cancer initiation and development is a dynamic and complex mechanism involving multiple genetic and non-genetic variations. With the development of high throughput techniques like next-generation sequencing, the field of cancer biology extended beyond the protein-coding genes. It brought the functional role of noncoding RNAs into cancer-associated pathways. MicroRNAs (miRNAs) are one such class of noncoding RNAs regulating different cancer development aspects, including progression and metastasis. MicroRNA-1 (miR-1) is a highly conserved miRNA with a functional role in developing skeletal muscle precursor cells and cardiomyocytes and acts as a consistent tumor suppressor gene. In humans, two discrete genes, MIR-1–1 located on 20q13.333 and MIR-1–2 located on 18q11.2 loci encode for a single mature miR-1. Downregulation of miR-1 has been demonstrated in multiple cancers, including lung, breast, liver, prostate, colorectal, pancreatic, medulloblastoma, and gastric cancer. A vast number of studies have shown that miR-1 affects the hallmarks of cancer like proliferation, invasion and metastasis, apoptosis, angiogenesis, chemosensitization, and immune modulation. The potential therapeutic applications of miR-1 in multiple cancer pathways provide a novel platform for developing anticancer therapies. This review focuses on the different antitumorigenic and therapeutic aspects of miR-1, including how it regulates tumor development and associated immunomodulatory functions.

Original languageEnglish (US)
Pages (from-to)114-126
Number of pages13
JournalSeminars in Cell and Developmental Biology
StatePublished - Apr 2022


  • Cancer therapeutics
  • Chemosensitivity
  • Immunoregulation
  • MiR-1
  • MiRNAs

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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