TY - JOUR
T1 - MicroRNA-1
T2 - Diverse role of a small player in multiple cancers
AU - Khan, Parvez
AU - Ebenezer, Nivetha Sarah
AU - Siddiqui, Jawed Akhtar
AU - Maurya, Shailendra Kumar
AU - Lakshmanan, Imayavaramban
AU - Salgia, Ravi
AU - Batra, Surinder Kumar
AU - Nasser, Mohd Wasim
N1 - Publisher Copyright:
© 2021
PY - 2022/4
Y1 - 2022/4
N2 - The process of cancer initiation and development is a dynamic and complex mechanism involving multiple genetic and non-genetic variations. With the development of high throughput techniques like next-generation sequencing, the field of cancer biology extended beyond the protein-coding genes. It brought the functional role of noncoding RNAs into cancer-associated pathways. MicroRNAs (miRNAs) are one such class of noncoding RNAs regulating different cancer development aspects, including progression and metastasis. MicroRNA-1 (miR-1) is a highly conserved miRNA with a functional role in developing skeletal muscle precursor cells and cardiomyocytes and acts as a consistent tumor suppressor gene. In humans, two discrete genes, MIR-1–1 located on 20q13.333 and MIR-1–2 located on 18q11.2 loci encode for a single mature miR-1. Downregulation of miR-1 has been demonstrated in multiple cancers, including lung, breast, liver, prostate, colorectal, pancreatic, medulloblastoma, and gastric cancer. A vast number of studies have shown that miR-1 affects the hallmarks of cancer like proliferation, invasion and metastasis, apoptosis, angiogenesis, chemosensitization, and immune modulation. The potential therapeutic applications of miR-1 in multiple cancer pathways provide a novel platform for developing anticancer therapies. This review focuses on the different antitumorigenic and therapeutic aspects of miR-1, including how it regulates tumor development and associated immunomodulatory functions.
AB - The process of cancer initiation and development is a dynamic and complex mechanism involving multiple genetic and non-genetic variations. With the development of high throughput techniques like next-generation sequencing, the field of cancer biology extended beyond the protein-coding genes. It brought the functional role of noncoding RNAs into cancer-associated pathways. MicroRNAs (miRNAs) are one such class of noncoding RNAs regulating different cancer development aspects, including progression and metastasis. MicroRNA-1 (miR-1) is a highly conserved miRNA with a functional role in developing skeletal muscle precursor cells and cardiomyocytes and acts as a consistent tumor suppressor gene. In humans, two discrete genes, MIR-1–1 located on 20q13.333 and MIR-1–2 located on 18q11.2 loci encode for a single mature miR-1. Downregulation of miR-1 has been demonstrated in multiple cancers, including lung, breast, liver, prostate, colorectal, pancreatic, medulloblastoma, and gastric cancer. A vast number of studies have shown that miR-1 affects the hallmarks of cancer like proliferation, invasion and metastasis, apoptosis, angiogenesis, chemosensitization, and immune modulation. The potential therapeutic applications of miR-1 in multiple cancer pathways provide a novel platform for developing anticancer therapies. This review focuses on the different antitumorigenic and therapeutic aspects of miR-1, including how it regulates tumor development and associated immunomodulatory functions.
KW - Cancer therapeutics
KW - Chemosensitivity
KW - Immunoregulation
KW - MiR-1
KW - MiRNAs
UR - http://www.scopus.com/inward/record.url?scp=85107046931&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85107046931&partnerID=8YFLogxK
U2 - 10.1016/j.semcdb.2021.05.020
DO - 10.1016/j.semcdb.2021.05.020
M3 - Review article
C2 - 34034986
AN - SCOPUS:85107046931
SN - 1084-9521
VL - 124
SP - 114
EP - 126
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
ER -