TY - JOUR
T1 - MicroRNA in pancreatic cancer
T2 - Pathological, diagnostic and therapeutic implications
AU - Rachagani, Satyanarayana
AU - Kumar, Sushil
AU - Batra, Surinder K.
N1 - Funding Information:
The authors on this work are supported by grants from the National Institutes of Health (CA78590, CA111294, CA133774 and CA131944).
PY - 2010/6
Y1 - 2010/6
N2 - MicroRNAs (miRNAs) are a group of small non-coding RNA molecules of 17-25 nucleotides (nt) in length, predicted to control the activity of about 30% of all protein-coding genes in mammals. Altered expressions of miRNAs are reported in various cancers and may associate with cancer pathogenesis, apoptosis, and cell growth, thereby functioning as either tumor suppressors or oncogenes. Recent reports showed that deregulation of miRNA contribute to tumor development and progression and hence, have diagnostic and prognostic value in several human malignancies. This review discusses the current status of miRNA in pancreatic cancer development, progression, diagnosis, and therapy.
AB - MicroRNAs (miRNAs) are a group of small non-coding RNA molecules of 17-25 nucleotides (nt) in length, predicted to control the activity of about 30% of all protein-coding genes in mammals. Altered expressions of miRNAs are reported in various cancers and may associate with cancer pathogenesis, apoptosis, and cell growth, thereby functioning as either tumor suppressors or oncogenes. Recent reports showed that deregulation of miRNA contribute to tumor development and progression and hence, have diagnostic and prognostic value in several human malignancies. This review discusses the current status of miRNA in pancreatic cancer development, progression, diagnosis, and therapy.
KW - Diagnosis and therapy
KW - MicroRNA
KW - Pancreatic cancer
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U2 - 10.1016/j.canlet.2009.11.010
DO - 10.1016/j.canlet.2009.11.010
M3 - Review article
C2 - 20004512
AN - SCOPUS:77951223405
SN - 0304-3835
VL - 292
SP - 8
EP - 16
JO - Cancer Letters
JF - Cancer Letters
IS - 1
ER -