MicroRNA Regulation of HDL Homeostasis

Xinghui Sun; Mark W. Feinberg

doi:10.1016/B978-0-12-812513-7.00010-0

MicroRNA Regulation of HDL Homeostasis

Xinghui Sun, Mark W. Feinberg

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

MicroRNAs (miRNAs) represent an important class of noncoding RNAs that play key roles in regulating the expression of genes in health and disease. Accumulating experimental, pathological, genetic, epidemiological, and clinical studies highlight a growing list of miRNAs that control lipoprotein homeostasis and high-density lipoprotein (HDL) metabolism. By "fine-tuning" the expression of genes or signaling networks, miRNAs actively modulate HDL biogenesis and function including efflux of cholesterol from the vessel wall, altering inflammatory responses, or facilitating reverse cholesterol transport. This chapter highlights emerging concepts in miRNA-mediated control of HDL homeostasis as well as some of the challenges and therapeutic opportunities in the pathogenesis of cardiovascular and metabolic diseases.

Original language	English (US)
Title of host publication	The HDL Handbook
Subtitle of host publication	Biological Functions and Clinical Implications: Third Edition
Publisher	Elsevier Inc.
Pages	209-229
Number of pages	21
ISBN (Print)	9780128125137
DOIs	https://doi.org/10.1016/B978-0-12-812513-7.00010-0
State	Published - Feb 22 2017
Externally published	Yes

Keywords

ABCA1
Atherosclerosis
CETP
Cardiovascular
Cholesterol
HDL
LCAT
LDL
Liver
Macrophage
Metabolism
MicroRNA
MicroRNA therapeutics
Reverse cholesterol transport
VLDL

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-12-812513-7.00010-0

Cite this

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title = "MicroRNA Regulation of HDL Homeostasis",

abstract = "MicroRNAs (miRNAs) represent an important class of noncoding RNAs that play key roles in regulating the expression of genes in health and disease. Accumulating experimental, pathological, genetic, epidemiological, and clinical studies highlight a growing list of miRNAs that control lipoprotein homeostasis and high-density lipoprotein (HDL) metabolism. By {"}fine-tuning{"} the expression of genes or signaling networks, miRNAs actively modulate HDL biogenesis and function including efflux of cholesterol from the vessel wall, altering inflammatory responses, or facilitating reverse cholesterol transport. This chapter highlights emerging concepts in miRNA-mediated control of HDL homeostasis as well as some of the challenges and therapeutic opportunities in the pathogenesis of cardiovascular and metabolic diseases.",

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AU - Feinberg, Mark W.

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AB - MicroRNAs (miRNAs) represent an important class of noncoding RNAs that play key roles in regulating the expression of genes in health and disease. Accumulating experimental, pathological, genetic, epidemiological, and clinical studies highlight a growing list of miRNAs that control lipoprotein homeostasis and high-density lipoprotein (HDL) metabolism. By "fine-tuning" the expression of genes or signaling networks, miRNAs actively modulate HDL biogenesis and function including efflux of cholesterol from the vessel wall, altering inflammatory responses, or facilitating reverse cholesterol transport. This chapter highlights emerging concepts in miRNA-mediated control of HDL homeostasis as well as some of the challenges and therapeutic opportunities in the pathogenesis of cardiovascular and metabolic diseases.

KW - ABCA1

KW - Atherosclerosis

KW - CETP

KW - Cardiovascular

KW - Cholesterol

KW - HDL

KW - LCAT

KW - LDL

KW - Liver

KW - Macrophage

KW - Metabolism

KW - MicroRNA

KW - MicroRNA therapeutics

KW - Reverse cholesterol transport

KW - VLDL

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M3 - Chapter

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SN - 9780128125137

SP - 209

EP - 229

BT - The HDL Handbook

PB - Elsevier Inc.

ER -

MicroRNA Regulation of HDL Homeostasis

Abstract

Keywords

ASJC Scopus subject areas

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