MicroRNAs are important regulators of drug resistance in colorectal cancer

Yang Zhang, Jing Wang

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

Despite of continuous development of cancer treatment over the past decades, drug resistance is still one of the major hurdles of effective therapy for advanced colorectal cancer (CRC) worldwide and the understanding of its underlying mechanisms remains limited. Data which have emerged suggests that many microRNAs (miRNAs) may contribute to drug resistance in CRC. Major findings on miRNA functions in drug resistance of CRC are systemically reviewed here, with the goal of providing new updates to broaden our comprehension of its mechanisms and evidence to utilize miRNAs as potential therapeutic targets for CRC treatment.

Original languageEnglish (US)
Pages (from-to)929-938
Number of pages10
JournalBiological Chemistry
Volume398
Issue number8
DOIs
StatePublished - Jul 26 2017

Keywords

  • apoptosis
  • chemoresistance
  • chemotherapy
  • colorectal cancer
  • drug resistance
  • miRNAs

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'MicroRNAs are important regulators of drug resistance in colorectal cancer'. Together they form a unique fingerprint.

Cite this