Microspheres of corn protein, zein, for an ivermectin drug delivery system

Xinming Liu, Qingshen Sun, Huajie Wang, Lei Zhang, Jin Ye Wang

Research output: Contribution to journalArticlepeer-review

290 Scopus citations


A novel microsphere drug delivery system of ivermectin (IVM) using hydrophobic protein zein was prepared by the phase separation method and characterized by a scanning electron microscope and laser light scattering particle size analyzer. Releases of model drug IVM from zein microspheres, tabletted microspheres and pepsin degradation of tabletted microspheres were also performed in vitro to investigate the mechanism of model drug release. The results show that the zein microspheres and tabletted microspheres are suitable for use as a sustained-release form of IVM. The microspheres may also be useful in drug targeting system since the diameter of the microspheres is appropriate for phagocytosis by macrophages. Moreover, the release of IVM from enzymatic degraded tabletted microspheres shows a zero-order release, implying a potential application in tissue engineering for preparing scaffold, which is composed of microspheres encapsulating bioactive components for stimulating cell differentiation and proliferation.

Original languageEnglish (US)
Pages (from-to)109-115
Number of pages7
Issue number1
StatePublished - Jan 2005


  • Biodegradation
  • Controlled drug release
  • Drug delivery
  • Electron microscopy
  • IVM, ivermectin
  • Microspheres
  • PLA, poly(lactic acid)
  • PLGA, poly(lactic-co-glycolic acid)
  • SEM, scanning electron microscope
  • SR, sustained-release

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials


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