Microvascular effects of atrial natriuretic peptide in rat cremaster

R. Wayne Barbee, Lisa M. Harrison-Bernard, Pamela K. Carmines

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Experiments utilized the open cremaster preparation to test the hypothesis that atrial natriuretic peptide (ANP)-induced volume changes result from microvascular resistance alterations. Atrial natriuretic peptide (25, 100, and 500 ng/kg/min, IV) or vehicle was infused into anesthetized rats. At the two highest ANP infusion rates, mean arterial pressure was significantly reduced from 104 ± 3 (control) to 87 ± 2 and 77 ± 2 mmHg, respectively. Hematocrit was 41.0 ± 0.8 and 45.6 ± 0.9% (p < 0.05) at the end of vehicle and ANP infusions, respectively. Despite these effects of ANP, there were no significant arteriolar or venular diameter alterations. Thirty μM nitroprusside significantly dilated all vessel segments except large venules. These observations suggest that resistance alterations in the skeletal muscle microvasculature are not the cause of ANP-induced fluid movement.

Original languageEnglish (US)
Pages (from-to)1181-1185
Number of pages5
Issue number6
StatePublished - 1992
Externally publishedYes


  • Arterioles
  • Central venous pressure
  • Hematocrit
  • Microcirculation
  • Skeletal muscle
  • Vascular smooth muscle
  • Venules

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience


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