Mild cognitive impairment and risk of mortality in HIV-1 infection

Frances L. Wilkie, Karl Goodkin, Carl Eisdorfer, Daniel Feaster, Robert Morgan, Mary Ann Fletcher, Nancy Blaney, Marianna Baum, Jose Szapocznik

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


HIV-1-associated cognitive impairment has only been preliminarily investigated for association with mortality. The authors examined 119 HIV-1-positive homosexual men (asymptomatic: n = 96; early symptomatic: n = 23). At follow-up (to 3.5 years), there were 105 survivors and 14 nonsurvivors. Those at the 25th percentile in response speeds and in long-term memory retrieval accuracy were at 6.4 (P < 0.02) and 3.5 (P < 0.05) times increased mortality risk, respectively, of those at the 75th percentile - independent of base-line CDC clinical stage, CD4 cell count, hemoglobin level, antiretroviral and prophylactic medication use, and sociodemographics. Cognitive impairment should be identified early - for maximization of both functional status and survival time.

Original languageEnglish (US)
Pages (from-to)125-132
Number of pages8
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number2
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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