Mineralized short nanofibers coupled with BMP-2 peptides for alveolar bone regeneration

Jingwei Xie, Sunil Kumar Boda, Hongjun Wang, Dong Wang, Richard A. Reinhardt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: The issue of bone loss in the oral cavity continues to be a perennial problem, especially in the older populations. With the high incidence of dental implants/ fixtures for missing teeth, the success of the surgical procedures in restorative dentistry is dictated by the quality and quantity of the supporting alveolar bone. In order to address the problem of alveolar bone loss and defects due to tumor, periodontitis or even post-extraction remodeling, the present study is the first report on the application of mineralized nanofiber fragments coupled with calcium binding osteoinductive BMP-2 peptides as synthetic graft material for oral bone regeneration. The ease of fabrication and application of cryocut mineralized nanofiber fragments as maxillofacial bone defect fillers present a promising alternative to the current dental bone graft formulations. Furthermore, the nanofiber segments may be utilized for other biomedical applications including soft tissue engineering and wound healing.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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  • Cite this

    Xie, J., Boda, S. K., Wang, H., Wang, D., & Reinhardt, R. A. (2019). Mineralized short nanofibers coupled with BMP-2 peptides for alveolar bone regeneration. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.