TY - GEN
T1 - Mineralized short nanofibers coupled with BMP-2 peptides for alveolar bone regeneration
AU - Xie, Jingwei
AU - Boda, Sunil Kumar
AU - Wang, Hongjun
AU - Wang, Dong
AU - Reinhardt, Richard A.
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: The issue of bone loss in the oral cavity continues to be a perennial problem, especially in the older populations. With the high incidence of dental implants/ fixtures for missing teeth, the success of the surgical procedures in restorative dentistry is dictated by the quality and quantity of the supporting alveolar bone. In order to address the problem of alveolar bone loss and defects due to tumor, periodontitis or even post-extraction remodeling, the present study is the first report on the application of mineralized nanofiber fragments coupled with calcium binding osteoinductive BMP-2 peptides as synthetic graft material for oral bone regeneration. The ease of fabrication and application of cryocut mineralized nanofiber fragments as maxillofacial bone defect fillers present a promising alternative to the current dental bone graft formulations. Furthermore, the nanofiber segments may be utilized for other biomedical applications including soft tissue engineering and wound healing.
AB - Statement of Purpose: The issue of bone loss in the oral cavity continues to be a perennial problem, especially in the older populations. With the high incidence of dental implants/ fixtures for missing teeth, the success of the surgical procedures in restorative dentistry is dictated by the quality and quantity of the supporting alveolar bone. In order to address the problem of alveolar bone loss and defects due to tumor, periodontitis or even post-extraction remodeling, the present study is the first report on the application of mineralized nanofiber fragments coupled with calcium binding osteoinductive BMP-2 peptides as synthetic graft material for oral bone regeneration. The ease of fabrication and application of cryocut mineralized nanofiber fragments as maxillofacial bone defect fillers present a promising alternative to the current dental bone graft formulations. Furthermore, the nanofiber segments may be utilized for other biomedical applications including soft tissue engineering and wound healing.
UR - http://www.scopus.com/inward/record.url?scp=85065430060&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065430060&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85065430060
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 485
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -