MiR-9 promotes microglial activation by targeting MCPIP1

Honghong Yao; Rong Ma; Lu Yang; Guoku Hu; Xufeng Chen; Ming Duan; Yeonhee Kook; Fang Niu; Ke Liao; Minggui Fu; Gang Hu; Pappachan Kolattukudy; Shilpa Buch

doi:10.1038/ncomms5386

MiR-9 promotes microglial activation by targeting MCPIP1

Honghong Yao, Rong Ma, Lu Yang, Guoku Hu, Xufeng Chen, Ming Duan, Yeonhee Kook, Fang Niu, Ke Liao, Minggui Fu, Gang Hu, Pappachan Kolattukudy, Shilpa Buch

Research output: Contribution to journal › Article › peer-review

138 Scopus citations

Abstract

Microglia participate in innate inflammatory responses within the central nervous system. The highly conserved microRNA-9 (miR-9) plays critical roles in neurogenesis as well as axonal extension. Its role in microglial inflammatory responses, however, remains poorly understood. Here we identify a unique role of miR-9 in mediating the microglial inflammatory response via distinct signalling pathways. MiR-9-mediated regulation of cellular activation involved downregulated expression of the target protein, monocyte chemotactic protein-induced protein 1 (MCPIP1) that is crucial for controlling inflammation. Results indicate that miR-9-mediated cellular activation involved signalling via the NF-κ B pathway, but not the β 2-catenin pathway.

Original language	English (US)
Article number	4386
Journal	Nature communications
Volume	5
DOIs	https://doi.org/10.1038/ncomms5386
State	Published - Jul 14 2014

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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@article{35900ab3230d49e096fe73a31a7edf57,

title = "MiR-9 promotes microglial activation by targeting MCPIP1",

abstract = "Microglia participate in innate inflammatory responses within the central nervous system. The highly conserved microRNA-9 (miR-9) plays critical roles in neurogenesis as well as axonal extension. Its role in microglial inflammatory responses, however, remains poorly understood. Here we identify a unique role of miR-9 in mediating the microglial inflammatory response via distinct signalling pathways. MiR-9-mediated regulation of cellular activation involved downregulated expression of the target protein, monocyte chemotactic protein-induced protein 1 (MCPIP1) that is crucial for controlling inflammation. Results indicate that miR-9-mediated cellular activation involved signalling via the NF-κ B pathway, but not the β 2-catenin pathway.",

author = "Honghong Yao and Rong Ma and Lu Yang and Guoku Hu and Xufeng Chen and Ming Duan and Yeonhee Kook and Fang Niu and Ke Liao and Minggui Fu and Gang Hu and Pappachan Kolattukudy and Shilpa Buch",

note = "Funding Information: The technical support of Qiao Chen, Ming Lu and Yaman Lu was highly appreciated. This work was supported by grants MH-068212, DA036157, DA020392, DA023397, DA024442 (S.B.) and DA030285 (H.Y.) from the National Institutes of Health.",

year = "2014",

month = jul,

day = "14",

doi = "10.1038/ncomms5386",

language = "English (US)",

volume = "5",

journal = "Nature communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

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TY - JOUR

T1 - MiR-9 promotes microglial activation by targeting MCPIP1

AU - Yao, Honghong

AU - Ma, Rong

AU - Yang, Lu

AU - Hu, Guoku

AU - Chen, Xufeng

AU - Duan, Ming

AU - Kook, Yeonhee

AU - Niu, Fang

AU - Liao, Ke

AU - Fu, Minggui

AU - Hu, Gang

AU - Kolattukudy, Pappachan

AU - Buch, Shilpa

N1 - Funding Information: The technical support of Qiao Chen, Ming Lu and Yaman Lu was highly appreciated. This work was supported by grants MH-068212, DA036157, DA020392, DA023397, DA024442 (S.B.) and DA030285 (H.Y.) from the National Institutes of Health.

PY - 2014/7/14

Y1 - 2014/7/14

N2 - Microglia participate in innate inflammatory responses within the central nervous system. The highly conserved microRNA-9 (miR-9) plays critical roles in neurogenesis as well as axonal extension. Its role in microglial inflammatory responses, however, remains poorly understood. Here we identify a unique role of miR-9 in mediating the microglial inflammatory response via distinct signalling pathways. MiR-9-mediated regulation of cellular activation involved downregulated expression of the target protein, monocyte chemotactic protein-induced protein 1 (MCPIP1) that is crucial for controlling inflammation. Results indicate that miR-9-mediated cellular activation involved signalling via the NF-κ B pathway, but not the β 2-catenin pathway.

AB - Microglia participate in innate inflammatory responses within the central nervous system. The highly conserved microRNA-9 (miR-9) plays critical roles in neurogenesis as well as axonal extension. Its role in microglial inflammatory responses, however, remains poorly understood. Here we identify a unique role of miR-9 in mediating the microglial inflammatory response via distinct signalling pathways. MiR-9-mediated regulation of cellular activation involved downregulated expression of the target protein, monocyte chemotactic protein-induced protein 1 (MCPIP1) that is crucial for controlling inflammation. Results indicate that miR-9-mediated cellular activation involved signalling via the NF-κ B pathway, but not the β 2-catenin pathway.

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VL - 5

JO - Nature communications

JF - Nature communications

M1 - 4386

ER -

MiR-9 promotes microglial activation by targeting MCPIP1

Abstract

ASJC Scopus subject areas

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