miRNAs in atherosclerotic plaque initiation, progression, and rupture

Ioannis Andreou, Xinghui Sun, Peter H. Stone, Elazer R. Edelman, Mark W. Feinberg

Research output: Contribution to journalReview article

80 Scopus citations

Abstract

Atherosclerosis is a chronic immune-inflammatory disorder that integrates multiple cell types and a diverse set of inflammatory mediators. miRNAs are emerging as important post-transcriptional regulators of gene expression in most, if not all, vertebrate cells, and constitute central players in many physiological and pathological processes. Rapidly accumulating experimental studies reveal their key role in cellular and molecular processes related to the development of atherosclerosis. We review current evidence for the involvement of miRNAs in early atherosclerotic lesion formation and in plaque rupture and erosion. We conclude with a perspective on the clinical relevance, therapeutic opportunities, and future challenges of miRNA biology in understanding the pathogenesis of this complex disease.

Original languageEnglish (US)
Pages (from-to)307-318
Number of pages12
JournalTrends in Molecular Medicine
Volume21
Issue number5
DOIs
StatePublished - May 1 2015

Keywords

  • Atherosclerosis
  • Inflammation
  • MiRNAs
  • Shear stress
  • Vulnerable plaque

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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