Mitochondrial Extracellular Vesicles in CNS Disorders: New Frontiers in Understanding the Neurological Disorders of the Brain

Mary F. Nakamya, Susmita Sil, Shilpa Buch, Ramin M. Hakami

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent findings have highlighted potential diagnostic and prognostic values of extracellular vesicles (EVs) that contain mitochondrial derived components for neurological disorders. Furthermore, functional influences of vesicles carrying mitochondrial components have been reported. In particular, this includes indications of crosstalk with mitophagy to influence progression of various CNS disorders. In this mini-review, we discuss the current state of knowledge about this intriguing class of vesicles in neurological disorders of the CNS, and outline the lacunae and thus scope of further development in this fascinating field of study.

Original languageEnglish (US)
Article number840364
JournalFrontiers in Molecular Biosciences
Volume9
DOIs
StatePublished - Mar 30 2022

Keywords

  • CNS disorders
  • extracellular vesicles
  • mitochondria
  • mitochondria-derived vesicles
  • mitochondrial dysfunction
  • mitophagy
  • oxidative stress

ASJC Scopus subject areas

  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Molecular Biology

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