Mitochondrial Quality Control Proteases in Neuronal Welfare

Roman M. Levytskyy, Edward M. Germany, Oleh Khalimonchuk

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


The functional integrity of mitochondria is a critical determinant of neuronal health and compromised mitochondrial function is a commonly recognized factor that underlies a plethora of neurological and neurodegenerative diseases. Metabolic demands of neural cells require high bioenergetic outputs that are often associated with enhanced production of reactive oxygen species. Unopposed accumulation of these respiratory byproducts over time leads to oxidative damage and imbalanced protein homeostasis within mitochondrial subcompartments, which in turn may result in cellular demise. The post-mitotic nature of neurons and their vulnerability to these stress factors necessitate strict protein homeostatic control to prevent such scenarios. A series of evolutionarily conserved proteases is one of the central elements of mitochondrial quality control. These versatile proteolytic enzymes conduct a multitude of activities to preserve normal mitochondrial function during organelle biogenesis, metabolic remodeling and stress. In this review we discuss neuroprotective aspects of mitochondrial quality control proteases and neuropathological manifestations arising from defective proteolysis within the mitochondrion.

Original languageEnglish (US)
Pages (from-to)629-644
Number of pages16
JournalJournal of Neuroimmune Pharmacology
Issue number4
StatePublished - Dec 1 2016


  • Hereditary neurological diseases
  • Mitochondria
  • Mitochondrial proteases
  • Mitochondrial quality control
  • Neurodegenerative diseases
  • Neurons

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology


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