Mitoproteome: Human heart mitochondrial protein sequence database

Purnima Guda, Shankar Subramaniam, Chittibabu Guda

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Abstract

The human mitochondrial proteome database has been developed by deriving data from, a combination of public repositories and experimental and computational prediction methods. The experimental data is derived from highly purified mitochondria from, human heart tissue, whereas predictions have been performed by MITOPRED, a genome-scale method for the prediction of nucleus-encoded mitochondrial proteins. Mitochondrial protein sequences from different sources have been clustered to generate a nonredundant dataset. Annotations related to the protein function, structure, disease association, pathways, and so on are collected from a number of public databases using commonly used UNIX and Perl scripts. This chapter provides a detailed description of various data sources and methods used to download, curate, parse, and generate meaningful annotations from, primary as well as derived databases.

Original languageEnglish (US)
Title of host publicationCardiovascular Proteomics
Subtitle of host publicationMethods and Protocols
EditorsFernando Vivanco
Pages375-383
Number of pages9
DOIs
StatePublished - Feb 5 2007

Publication series

NameMethods in Molecular Biology
Volume357
ISSN (Print)1064-3745

Keywords

  • Biological database
  • Human heart
  • MITOPRED
  • Mitochondria
  • Mitoproteome

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Guda, P., Subramaniam, S., & Guda, C. (2007). Mitoproteome: Human heart mitochondrial protein sequence database. In F. Vivanco (Ed.), Cardiovascular Proteomics: Methods and Protocols (pp. 375-383). (Methods in Molecular Biology; Vol. 357). https://doi.org/10.1385/1-59745-214-9:375